对氨基三氟甲苯的合成方法  

Preparation Procedure of p-Aminobenzotrifluoride

作　　者：周洪钟[1,2] 杜晓华[1] 陈静华[1,2] 刘海辉[1] 徐振元[1] 

机构地区：[1]浙江工业大学催化加氢研究中心,杭州310014 [2]浙江巍华化工有限公司,浙江金华322100

出　　处：《农药》2009年第3期174-176,共3页Agrochemicals

基　　金：浙江省科技计划重点项目(2005C21039)

摘　　要：以对甲苯胺为起始原料,经异氰酸酯化、侧链氯化和氟化-溶剂解3步反应合成对氨基三氟甲苯。研究了双(三氯甲基)碳酸酯替代光气、光氯化及氟化—溶剂解"一锅法"等单元过程的优惠工艺条件。总收率达到82%,适合工业化应用。p-Aminobenzotrifluoride was prepared by p-toluidine, comprising 3 steps of isocyanation, chain chlorination and fluorination-solvolysis. The optimum conditions were investigated, including the phosgene replacement with bis（trichloromethyl）carbonate, chlorination under UV light and fluorination-solvolysis in one pot. A total yield up to 82% was obtained. The procedure is applicable for the scale manufacture of the title compound.

关 键 词：对氨基三氟甲苯 合成 对甲苯胺 

分 类 号：TQ246.34[化学工程—有机化工]