儿童支气管哮喘血清IL-4、IFN-γ、TGF—β1和IL-10的变化及临床意义  

Changes of Serum IL-4, IFN-γ, TGF-βI and IL-10 Levels in Bronchial Asthma in Children and Its Clinical Significance

作　　者：卢彦 黄兴楚 宋承东 

机构地区：[1]湖北省潜江中心医院儿科,湖北潜江433100

出　　处：《医学临床研究》2009年第2期231-233,共3页Journal of Clinical Research

摘　　要：[目的]探讨与T淋巴细胞失衡相关的血清炎症因子IL4、IFN-γ和TGF-β1、IL-10在支气管哮喘患儿中的变化及其临床意义。[方法]采用酶联双抗夹心法（ELISA）检测50例支气管哮喘患儿和30例健康儿童血清中IL-4、IFN-γ和TGF-β1、IL-10水平。[结果]与对照组比较，哮喘组IL4水平[（72．33±34．74）vs（38．17±17．12）pg／mL]．显著升高（P〈0．01），而IFN-γ[（8．36±4．25）vs（10．57±3．58）ng／mL]、TGF-β1[（12．42±4．34）vs（26．14±6．32）ng／mL]和IL-10[（22．76±15．28）VS（38．28±15．17）pg／mL]水平显著降低（P〈0．05）；TGF-β1和IL-10明显正相关（r=0．465，P〈0．01）。[结论]支气管哮喘患儿IL，4、IFN-γ和TGF-β1、IL-10紊乱可能因Th1／Th2功能失衡和Treg发育分化缺陷所致，调节气道T淋巴细胞失衡及相关炎症因子表达将是哮喘防治的一个重要靶点。[Objective]To explore the changes of IL-4, IFN-γ, TGF-β1 and IL-10 related to T-lymphocyte imbalance in bronchial asthma in children and its clinical significance. [Methods] Serum IL-4, IFN-γ, TGF-β1 and IL-10 of 50 bronchial asthma and 30 health controls were detected by using ELISA method. [Results] Serum IL-4 level of asthma was obviously high compared with normal group（72.33 ±34.74 vs 38.17±17.12pg/ mL） （ P 〈0. 01）. Compared with normal group, serum levels of IFN-γ（8. 36±4. 25 vs 10.57±3.58 ng/mL）, TGF-β1（12. 42±4. 34 vs 26.14±6.32 ng/mL） and IL-10（22.76±15.28 vs 38.28±15.17 pg/mL） in asthma group were markedly low（ P 〈0.05）. There was good positive correlation between TGF-β1 and IL-10 （r= 0. 465 P 〈0.01）. [ConclusionlDysfunction of IL-4, IFN-γ, TGF-β1 and IL-10 may be caused by T-lymphocyte imbalance and the deficiency of Treg development and differentiation. Regulating the expression of related inflammatory factors will be an important target of prevention and cure of bronchial asthma in children.

关 键 词：哮喘/血液 白细胞介素4/血液 干扰素Ⅱ型/血液 转化生长因子β/血液 白细胞介素10/血液 

分 类 号：R725.622.5[医药卫生—儿科]