牛奶及奶制品对胃癌发病影响的综合分析  

Meta-analysis of the relationship between dairy product consumption and gastric cancer

作　　者：黄月香[1] 秦立强[2] 王培玉[1] 

机构地区：[1]北京大学公共卫生学院营养与食品卫生学系,100083 [2]苏州大学放射医学与公共卫生学院放射医学系

出　　处：《中华预防医学杂志》2009年第3期193-196,共4页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金（30471448）

摘　　要：目的 探讨食用牛奶及奶制品与胃癌发生的关系。方法查阅中国期刊全文数据库（CNKI）、中国生物医学文献数据库、万方数据库（1985年1月—2008年6月）、中文科技期刊全文数据库（1989年1月～2008年6月）以及手工检索，收集国内研究文献和学位论文，采用主题词、关键词及全文相结合的方法进行检索，检索词选用胃癌、饮食、牛奶或奶制品，利用综合分析方法定量分析纳入标准的文献。结果共有8篇病例对照研究纳入综合分析，累计病例1684例，对照5410例。异质性检验结果显示Q=9．52（df=7），查X^2界值表P〉0．1，说明8篇研究没有明显的异质性，因此采用固定效应模型进行分析，结果显示食用牛奶及奶制品与胃癌发生之间的合并比值比（OR）为0．57，95％的可信区间（95％CI）为0．46—0．71，失效安全数为43．84。结论食用牛奶及奶制品可减少胃癌发病的风险。Objective To clarify the effect of milk consumption on gastric cancer in China. Methods China National Knowledge Infrastructure （CNKI） and other Chinese databases were searched for randomized controlled trials reporting the relationship between dairy products consumption and gastric carcinoma patients from January 1985 to June 2008. Manual searching was also performed. Gastric carcinoma, dietary, milk or diary product were using as key words. A Meta-analysis method was applied to estimate the combined odds ratio （OR） and 95% confidence interval （95% CI） between dairy product consumption and gastric cancer. Results Eight case-control studies published between 1985 and 2008 were selected for Meta-analysis. The cumulative cases and controls were 1684 and 5410, respectively. Fixed-effect model was used because of homogeneity among these studies. The overall pooled OR estimate was 0. 57 （95% CI = 0. 46 - 0.71 ）, suggesting a negative association between dairy product consumption and gastric cancer. Conclusion This Meta-analysis supports the hypothesis that dairy product consumption might decrease the risk of gastric cancer.

关 键 词：乳 胃肿瘤 META分析 

分 类 号：R686[医药卫生—骨科学]