难治性哮喘患病相关因素的回顾性分析  

Retrospective analysis of factors associated with refractory asthma

作　　者：黄志俭[1] 罗琴[1] 祖里培亚[1] 王维[1] 凌敏[1] 李芬宇[1] 

机构地区：[1]新疆维吾尔自治区人民医院呼吸二科,乌鲁木齐830001

出　　处：《中华全科医师杂志》2009年第3期191-193,共3页Chinese Journal of General Practitioners

摘　　要：收集分析2006年1月至2008年2月于我院住院治疗的重症哮喘74例患者的资料，其中治疗控制组36例，难治组38例。难治组中，职业暴露和环境气候因素为24例（63．2％），所占比例最高，两组间差异有统计学意义（P〈0．05）；合并鼻炎为17例（44．7％），胃食管反流为15例（39．5％），过敏性肉芽肿性血管炎1例（2．6％），支气管内膜结核2例（5．3％），过敏性支气管肺曲菌病1例（2．6％），合并阻塞性睡眠呼吸暂停综合征者1例（2．6％），吸烟者所占比例虽高于哮喘控制组，但组间差异无统计学意义（P〉0．05）。Seventy four patients with severe asthma were admitted from January of 2006 to February of 2008. Among them 36 patients suffered from controlled severe asthma, 38 with difficult controlled asthma. The demographic information, occupational environmental exposure, smoking history and accompanied diseases were analyzed. In refractory asthma group, occupational and environmental exposure （ 24, 63.2% ） and poor compliance （22, 57. 9% ） were significantly associated with the disease（ P 〈 0. 05 ） ; The rates of rhinitis （ 17, 44. 7% ） , gastroesophageal reflux disease （ 15, 39. 5% ）, allergic bronchopulmonary aspergillosis （ 1,2. 6% ） , churg-strauss syndrome （ 1, 2. 6% ） , obstructive sleep apnea （ 1, 2. 6% ） , endotracheal tuberculosis （2,5.3 % ） and smoking were higher than those of controlled severe asthma group, however, without the statistical significance（ P 〉 0. 05 ）. Conclusions Occupational exposure, environmental exposure and poor compliance were the major risk factors for refractory asthma.

关 键 词：哮喘 患者 临床分析 睡眠呼吸暂停综合征者 

分 类 号：R562.25[医药卫生—呼吸系统]