吉非罗齐对高脂饮食喂养的兔心肌缺血再灌注损伤的保护作用  

Protective Effect of Gemifibrozil on Myocardial Ischemia Reperfusion Injury in Rabbits Fed by High Diet

作　　者：涂丽珍[1] 吴洁[1] 韦兵[2] 杜克炜[1] 谷祥任[1] 黄健[1] 金海燕[3] 丁翠芬[4] 

机构地区：[1]南华大学第一附属医院心内科,湖南衡阳421001 [2]南华大学第一附属医院心胸外科 [3]南华大学机能实验室 [4]南华大学第二附属医院心内科

出　　处：《南华大学学报（医学版）》2008年第6期731-734,共4页Journal of Nanhua University(Medical Edition)

基　　金：湖南省卫生厅基金项目资助(编号C2006-028)

摘　　要：目的探讨吉非罗齐对高脂饮食喂养的兔心肌缺血再灌注损伤的保护作用。方法选用24只新西兰兔分成缺血再灌注组(I/R组)、吉非罗齐治疗+缺血再灌注组(GF+I/R组)和假手术组。测定缺血前后及再灌注后各组兔血浆CK、LDH、CRP和IL-6的变化,观察各组兔心肌梗死范围,并用电镜观察心肌超微结构的变化,光镜观察心肌炎症细胞浸润。结果I/R组与GF+I/R组在缺血后及再灌注后血浆CK、LDH、CRP、IL-6明显高于假手术组(P<0.01)。I/R组CK、LDH、CRP、IL-6值明显高于GF+I/R组(P<0.01)。GF+I/R组较I/R组心肌梗死面积减少(P<0.05)。光镜及电镜观察可见吉非罗齐能明显减轻心肌病理损伤。结论吉非罗齐对心肌缺血再灌注损伤有保护作用,其机制可能与抑制炎症反应有关。Objective To study the protective effect of gemifibrozil on myocardial ischemia reperfusion in rabbits fed by high diet. Methods 24 New Zealand rabbits were divided into ischemia reperfusion group（I/R）,gemifibrozil treatment and ischemia reperfusion group（GF＋I/R） and sham operation group.The plasma levels of CK,LDH,IL-6,CRP in each group were measured before ischemia and after reperfusion,and the size of infarct myocardium were detected in each group,the myocardial ultrastruction alteration with electron microscope and inflammatory cells aggregation of myocardium with microscope were observed at the same time. Result The levels of CK,LDH,CRP,IL-6 of the I/R group and GF＋I/R group were higher than that of sham operation group after ischemia and after reperfusion（P〈0.01）.The plasma levels of CK,LDH,CRP,IL-6 of the I/R group were higher than that of GF＋I/R group after ischemia reperfusion（P〈0.01）.The myocardial infarct size was significantly smaller in GF＋I/R group than the I/R group（P〈0.05）.Gemifibrozil could reduce significantly myocardial injury observed by microscope and electric microscope.Conclusion Gemifibrozil provides a protective effect against myocardial ischemia reperfusion injury in rabbits.This cardioprotection might be mediated through antiinflammatory mechanisms.

关 键 词：吉非罗齐 心肌缺血再灌注损伤 IL-6 CRP 

分 类 号：R542.2[医药卫生—心血管疾病]