Post-marketing Surveillance for Combined Oral Contraceptive Containing Desogestrel(Marvelon~) in Chinese Rural Areas  

作　　者：Hong-yan TANG Ying LI Yu-lin WU Jian ZHOU Lei BA Xiao-ping GU Wei-dong WANG Hui YAO Nai-xiu REN Jian-hong CHEN Lian-fang XU 

机构地区：[1]Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China [2]NPFPC Contraceptives Adverse Reaction Monitoring Center, Nanjing 210036, China [3]Jiangsu Research Centre for Reproductive Health in Humans, Nanjing 210036, China [4]Jianhu Institute of Family Planning Technical Instruction, Yancheng 224700, China [5]Gaoyou Institute of Family Planning Technical Instruction, Yangzhou 225600, China [6]Rudong Institute of Family Planning Technical Instruction, Nantong 226400, China [7]Taicang Institute of Family Planning Technical Instruction, Suzhou 215400, China [8]Jintan Institute of Family Planning Technical Instruction, Changzhou 213200, China [9]Changzhou Center for Disease Control and Prevention, Changzhou 213003, China

出　　处：《Journal of Reproduction and Contraception》2008年第4期193-200,共8页生殖与避孕（英文版）

基　　金：funded by the National Tenth Five-year Key Project (2002BA709B06)

摘　　要：To assess the side effects and the continuation rate of combined oral contraceptive （COC） containing desogestrel （Marvelon） during 12 months. Methods This was a post-marketing surveillance study on Marvelon COC among 870 healthy rural women in 5 different counties of Jiangsu Province during 12 months. Results About 24.02% of the women who used Marvelon COC experienced side effects during 12 months. Gastrointestinal disorder, bleeding/spotting and chloasma were ranked the first three in the side effects. The rate of side effects of Marvelon COC users during the first 3 months in southern area of Jiangsu was significantly higher than that of users in northern area of Jiangsu. Most of the users did not experience obvious weight changes i.e., loss or increase in weight of more than 5 kg during 12 months. Blood pressure and biochemical indicators of almost 99% among users were within the normal range. The gross cumulative continuation rate for 12 months was 83.14%; the most common medical reason for discontinuation was gastrointestinal disorder. There was an increased risk of discontinuation use among women with lower educational level. Conclusion Marvelon COC brought fewer side effects and was well accepted when applied in Chinese rural women.To assess the side effects and the continuation rate of combined oral contraceptive （COC） containing desogestrel （Marvelon） during 12 months. Methods This was a post-marketing surveillance study on Marvelon COC among 870 healthy rural women in 5 different counties of Jiangsu Province during 12 months. Results About 24.02% of the women who used Marvelon COC experienced side effects during 12 months. Gastrointestinal disorder, bleeding/spotting and chloasma were ranked the first three in the side effects. The rate of side effects of Marvelon COC users during the first 3 months in southern area of Jiangsu was significantly higher than that of users in northern area of Jiangsu. Most of the users did not experience obvious weight changes i.e., loss or increase in weight of more than 5 kg during 12 months. Blood pressure and biochemical indicators of almost 99% among users were within the normal range. The gross cumulative continuation rate for 12 months was 83.14%; the most common medical reason for discontinuation was gastrointestinal disorder. There was an increased risk of discontinuation use among women with lower educational level. Conclusion Marvelon COC brought fewer side effects and was well accepted when applied in Chinese rural women.

关 键 词：combined oral contraceptive DESOGESTREL side effects continuation rate 

分 类 号：R195[医药卫生—卫生统计学] R979.21[医药卫生—卫生事业管理]