N',N”-双(5-烷基-1,3,4-噻二唑-2-)基对苯二甲酰基双硫脲的合成与生物活性  

Synthesis and bioactivities of N',N"-bis(5-alkyl-1,3,4-thiodiazole-2-)yl terephthaloyl bisthioureas

作　　者：王微宏[1] 钟宏[1] 张文灵[1] 

机构地区：[1]中南大学化学化工学院,湖南长沙410083

出　　处：《中南大学学报（自然科学版）》2009年第1期67-71,共5页Journal of Central South University:Science and Technology

基　　金：国家自然科学基金资助项目(20476105);中南大学研究生教育创新工程资助项目(75208);中南大学文理研究基金资助项目(0601045)

摘　　要：为寻找高活性的含杂环农药,由中间体5-烷基-2-氨基-1,3,4-噻二唑与对苯二甲酰基二异硫氰酸酯反应,合成6种新的含1,3,4-噻二唑环的对苯二甲酰基双硫脲化合物Ⅲa-f。通过元素分析、红外光谱、核磁共振氢谱对所合成的化合物进行结构表征。生物活性测试结果表明:所合成的目标化合物对受试菌种小麦赤霉病菌,水稻纹枯病菌、棉枯萎病菌和油菜菌核病菌均表现出一定的抑制活性,但对棉枯萎病菌的抑制活性均较差。其中化合物Ⅲa和Ⅲb分别对油菜菌核病菌和水稻纹枯病菌有较强的抑制活性,抑制率分别为40.4%和51.6%,而Ⅲf的抑菌活性较弱。In order to find high active pesticide containing heterocycle, six novel terephthaloyl bisthioureas（Ⅲa-f） containing 1, 3, 4-thiodiazole were synthesized by the reaction of 2-amino-5-alkyl-1, 3, 4-thiodiazoles with terephthaloyl diisothiocyanate. Their structures were confirmed by elemental analysis, IR spectra and ^1HNMR. The preliminary biological activity tests show that the title compounds have some fungicidal activities using Gibberella zeae, Rhizoctonia solani, Fusarium oxysporium and Sclerotinia sclerotiorum as the target fungus, but all of them have poor fungicidal activity to Fusarium oxysporium. The compounds Ⅲa and Ⅲb have good fungicidal activity to Sclerotinia sclerotiorum and Rhizoctonia solanL and their inhibition ratios are 40.4% and 51.6%, respectively.

关 键 词：1 3 4-噻二唑 硫脲 生物活性 合成 

分 类 号：O621[理学—有机化学]