急性局灶性颅内压升高动物模型的建立及颅内压升高对经颅多普勒频谱影响的实验研究  

Experimental study in establishment of acute intracranial hypertension model and the effect of intracranial hypertension upon pattern of transcranial Doppler

作　　者：万景雯 吴钢[2] 林建东[3] 郑依勇[4] 

机构地区：[1]宁波鄞州人民医院神经内科,315040 [2]福建医科大学附属第一医院神经内科 [3]福建医科大学附属第一医院重症监护病房 [4]福建医科大学附属第一医院TCD室

出　　处：《中华超声影像学杂志》2009年第2期163-166,共4页Chinese Journal of Ultrasonography

摘　　要：目的建立急性局灶性颅内高压动物模型，探讨兔颅内高压状态下经颅多普勒（TCD）频谱动态变化规律，为临床应用TCD无创监测颅内压（ICP）、脑灌注压（CPP）提供实验依据。方法用硬膜外球囊注水法制作急性局灶性颅内高压动物模型，持续监测兔ICP、CPP及基底动脉TCD。结果随着颅内压升高，依次出现5种典型的TCD频谱：高阻力血流频谱、收缩峰、舒张期逆向血流、极小的收缩峰、无血流。结论根据TCD频谱变化能够定性判断颅内压和脑灌注压。本动物模型简便、严密，具有推广价值。Objective To establish the animal model of acute intracranial hypertension,investigate the changes of transcranial Doppler patterns in raised intracranial pressure so that the necessary experimental evidence will be provided to clinical experience for monitoring intracranial pressure （ICP） and cerebral perfusion pressure （CPP） using transcranial Doppler non-invasively. Methods Acute intracranial hypertension was induced by inflating the balloon inserted into the epiduraI space. Blood flow velocity of basilar artery was measured with transcranial Doppler and intracranial pressure as well as cerebral perfusion pressure was measured. Results With progressive increase of intracranial pressure five characteristic flow patterns were observed,appearing in the following order： high resistance pattern, systolic flow, retrograde diastolic flow, very small systolic flow and zero flow. Conclusions Analysing patterns of TCD may be helpful for evaluating ICP and CPP qualitatively. The animal model is simple and strict so that it is worthy of being spreaded.

关 键 词：超声检查 多普勒 经颅 颅内高压 颅内压 脑灌注压 

分 类 号：R686[医药卫生—骨科学]