SPF级与普通级小型猪主要脏器形态与脏器系数比较  

Comparison of Gross Findings and Relative Weight of Organs in SPF and Conventional WZS Minipigs

作　　者：黎立[1] 郭雄明[2] 姚春涛[2] 赵玉琼[2] 苟鹏[2] 王凯[2] 李春海[2] 陈华[2] 

机构地区：[1]解放军总医院第二附属医院结核病研究所,北京100091 [2]解放军总医院医学实验动物中心,北京100853

出　　处：《中国比较医学杂志》2009年第2期43-45,52,F0003,共5页Chinese Journal of Comparative Medicine

摘　　要：目的比较两种不同微生物学控制等级的五指山小型猪主要脏器重量和相对重量差异。方法选取4月龄近交培育的五指山猪20头,其中普通级和SPF级各10头,雌雄各半,分别测定体重和7种主要脏器重量,分析两种不同微生物控制程度的小型猪主要脏器形态及脏器相对重量。结果SPF级小型猪体重显著低于普通级对照(P<0.01),前者肺和脾的形态发生改变,肝、心、脑和肾上腺的相对重量显著高于普通级对照(P<0.01),而SPF级的脾和肺的相对重量显著低于普通级对照(P<0.01)。结论小型猪在不同微生物控制程度下体重和脏器系数存在显著差异,主要脏器形态与脏器系数差异可作为实验动物质量鉴定的参考依据。Objective To compare the organ weight and relative weight between SPF and conventional minipigs. Methods Ten male and 10 female minipigs were divided into SPF and conventional groups. The weight and relative weight of seven organs were analyzed. Results The body weight of minipigs in the SPF group was significantly lower than that in conventional group. The gross findings of lung and spleen were changed in the Wuzhishan minipigs. The relative weight of liver, heart, brain and adrenal gland in the SPF minipigs was significantly higher than that in conventional group while its relative weight of the lung and spleen was significantly lower than that in the conventional group. Conclusion There are some differences of the organ form and organ to body weight between SPF and conventional minipigs, and the above described data may be used as physiological indexes in the laboratory animals.

关 键 词：五指山小型猪 脏器重量 脏器系数 无特定病原体 

分 类 号：R446.11[医药卫生—诊断学]