光学相干断层扫描支气管镜的临床应用  

Optical coherence tomography bronchoscopy in clinic

作　　者：张骅 徐鹏 张民[3] 苏仁意 

机构地区：[1]襄樊市第一人民医院呼吸内科,湖北省襄樊市441000 [2]襄樊市第一人民医院急诊科,湖北省襄樊市441000 [3]华中科技大学同济医学院附属襄樊医院心血管内科,湖北省襄樊市441021

出　　处：《中国组织工程研究与临床康复》2009年第4期726-730,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：光学相干断层扫描影像成像技术适用于可弯曲支气管镜检查,它在肺部病变诊断上具有重要的作用和潜力。目前流行的诊断性影像学在探测人类支气管的气道形态、早期的疾病形态变化和实时区别肺部疾病的非特异性病理学变异方面,不具有充分的分辨率和组织穿透能力。光学相干断层扫描具有的空间分辨率再现了支气管的剖面、外形,能获得高分辨率、横断面组织学的缩微图像,可以认为其光学活组织检查能够取代常规的切除活组织检查。它是一种高度可行的光学工具,实时检测并获得接近组织学成像的支气管内的病理学,在肺部疾病的监测、(鉴别)诊断和治疗上是很有潜力的。光学相干断层扫描现在的应用策略是内窥镜检查对病变的早期诊断。光学的活组织检查通过使用光学相干断层扫描系统追踪、观察和评估治疗的效果。Optical coherence tomography （OCT） is an imaging technology that may be adapted for flexible fiberoptic bronchoscopy, potentially playing an important role in pulmonary diagnostics. Current diagnostic imaging modalities for human bronchial airways do not possess sufficient resolution and tissue penetration depth when detecting early morphologic changes and differentiating in real-time pulmonary disease pathology from nonspecific aberrations. OCT possesses the requisite high spatial resolution for reproducible delineation of endobronchial wall profiling. OCT can obtain high-resolution, cross-sectional microimages of tissue potentially allowing for optical biopsy to substitute for conventional excisional biopsy. It is a highly feasible optical tool for real-time near-histologic imaging of endobronchial pathology with potential application for pulmonary disease surveillance, diagnosis and treatment. OCT could remedy the present strategies for endoscopic early diagnosis. Optical biopsy follows up, observes and evaluates treatment outcome using OCT system.

关 键 词：支气管镜 光学相干断层扫描 周围性肺疾病 介入性肺病学 

分 类 号：R197.39[医药卫生—卫生事业管理]