脑钠肽对糖耐量减低患者合并冠心病的影响及预测冠状动脉狭窄程度的作用  

Effect of brain natriuretic peptide on patients with impaired glucose tolerance complicated with coronary heart disease and the predicting role in coronary artery stenosis degree

作　　者：熊攀[1] 周莉[2] 殷彩玲[1] 侯玉娟[1] 

机构地区：[1]泰山医学院附属聊城市第二人民医院心内科,山东省临清市252600 [2]泰山医学院附属聊城市第二人民医院病理科,山东省临清市252600

出　　处：《中华实用诊断与治疗杂志》2009年第3期256-258,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的:探讨脑钠肽对糖耐量减低患者合并冠心病影响及对冠状动脉狭窄程度的预测作用。方法:126例糖耐量减低患者均行冠状动脉造影术,分为冠状动脉正常组31例,单支病变组35例,双支病变组32例,3支病变组28例,并发冠心病者按临床类型分为稳定型心绞痛组(30例)、不稳定型心绞痛组(33例)和急性心肌梗死组(32例),所有患者检测脑钠肽浓度,比较各组脑钠肽水平。结果:急性心肌梗死组的脑钠肽水平明显高于其他3组(P<0.01),不稳定型心绞痛组脑钠肽水平高于稳定型心绞痛组及对照组(P<0.01),稳定型心绞痛组脑钠肽虽高于冠状动脉正常组,但差异无统计学意义(P>0.05),随着冠状动脉狭窄程度的加重,脑钠肽水平逐渐上升,冠状动脉病变各组与冠状动脉正常组比较,差异有统计学意义(P<0.01),双支病变组与单支病变组,3支病变组与双支病变组比较,差异均有统计学意义(P<0.01)。结论:脑钠肽可预测糖耐量减低患者并发冠心病,其水平随冠状动脉狭窄程度增加而升高。Objective To study the brain effect of natriuretic peptide in patients with impaired glucose tolerance and coronary heart disease and the predicting role in coronary artery stenosis. Methods One hundred and twenty six cases of impaired glucose tolerance received coronary angiography, in which coronary artery was normal in 31 cases, 35 cases had single-vessel lesions, 32 had double-vessel lesions, and 28 had three-vessel lesions. The patients with coronary heart disease were divided into stable angina pectoris group （30 cases）, unstable angina pectoris group （33 cases） and acute myocardial infarction group（32 cases）. All patients were detected and compared the brain natriuretic peptide concentration. Results The brain natriuretic peptide level was significantly higher in myocardial infarction group than the other three groups （P〈0.01）, and it was higher in unstable angina pectoris group than in the stable angina pectoris group and control group （P〈0.01）. It was higher in stable angina pectoris than in control, but there was no statistic difference（P〉0.05）. With the increase of coronary artery stenosis degree, brain natriuretic peptide level raised gradually, and there was statistic difference between coronary artery disease group and control group（P〈0.01）. It was statistically different in double-vessel lesions patients from single-vessel and three-vessel lesions patients（P〈0.01）. Conclusion Brain natriuretic peptide level can predict coronary heart disease with impaired glucose tolerance, and gets higher with the severe degree of coronary artery stenosis.

关 键 词：冠心病 糖耐量减低 脑钠肽 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]