血栓性疾病患者外周血IL-6、IL-8、IL-10及TNF-α水平及意义探讨  

Significance of Level of Inflammatory Cytokines in Patients with Acute Thrombosis

作　　者：袁平[1] 周翔宇[2] 周述芝[3] 何延政[2] 

机构地区：[1]泸州医学院附属医院神经内科,四川泸州646000 [2]泸州医学院附属医院血管外科,四川泸州646000 [3]泸州医学院附属医院麻醉科,四川泸州646000

出　　处：《中国临床医学》2009年第1期20-21,共2页Chinese Journal of Clinical Medicine

基　　金：四川省卫生厅科研基金资助项目(编号010020);泸州医学院2005年科研计划项目课题(05085)

摘　　要：目的:探讨炎性细胞因子IL-6、IL-8、IL-10、TNF-α在血栓性疾病中的水平及意义。方法:选择40例未经治疗的急性脑梗死(CI)患者作为动脉血栓疾病组(称作AT组),40例未经治疗的下肢深静脉血栓形成(DVT)患者40例作为静脉血栓组(VT组),与前2组年龄、性别比无统计学差异的健康志愿者30例作为对照组(NT组)。均在发病后48h内采集血液。用放射免疫分析检测血浆IL-6、IL-8、TNF-α水平,用酶联免疫吸附试验检测血浆IL-10水平。并对各组间细胞因子水平进行比较分析。结果:与NT组相比,AT组和VT组IL-6、IL-8、IL-10及TNF-α水平均明显升高,差异有统计学意义(P<0.001)。结论:炎性细胞因子IL-6、IL-8、IL-10及TNF-α在血栓性疾病中起着重要的作用。Objective：To study the significance of level of plasma inflammatory cytokines in patients with acute thrombosis. Methods： Forty never treated CI subjects and forty never treated DVT subjects have been selected to study. Thirty healthy subjects were studied as control groups. Radioimmuno assay（RIA） were used to detect plasma level of IL-6, IL-8, and TNF-α, Enzyme-linked immunosorbent assay （ELISA） were used to measure plasma level of IL-10. Results： The levels of plasma cytokines in the CI and VT groups were increased markedly compared with normal control（P〈0. 001 ）. Conclusion： Inflammatory cytokines plays an important role in acute thrombosis.

关 键 词：血栓形成 细胞因子 炎症 

分 类 号：R543[医药卫生—心血管疾病]