胸腔镜心包开窗术治疗难治性恶性心包积液的价值  

The Evaluation of Pericardial Window by Video-assisted Thoracoscopic Surgery in the Treatment of Malignant Pericardial Effusion

作　　者：方勇[1] 倪旭东[1] 谭黎杰[2] 

机构地区：[1]复旦大学附属中山医院分部胸外科,上海200052 [2]复旦大学附属中山医院胸外科,上海200032

出　　处：《中国临床医学》2009年第1期162-163,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:评价胸腔镜心包开窗术治疗难治性恶性心包积液的效果。方法:对32例难治性恶性心包积液患者行胸腔镜心包开窗术。比较治疗前、后生活质量Karnofsky评分。结果:心包积液完全缓解率为100%,疾病进展时间10.7个月,中位生存期12.3个月。Karnofsky评分治疗前(68.8±1.7)分,治疗后(90.8±2.3)分,有显著差异(t=9.92,P<0.01)。结论:胸腔镜心包开窗手术治疗难治性恶性心包积液能有效地提高生活质量和延长生存时间,可考虑作为难治性恶性心包积液的首选治疗方法。Objects： To evaluate the efficacy of the pericardial window by video-assisted thoracoscopic surgery to treat the malignant pericardial effusion. Methods：32 patients with refractory malignant pericardial effusion underwent pericardial window treatment by video-assisted thoracoscopic surgery. The life quality scores before and after surgery were assessed with the Karnofsky score evaluation criteria. The result was compared with t-test, the inter-group comparison was analyzed with one way analysis of variance. Results：The completed response（CR） rate of pericardial effusion, time to progress（TTP） and median survival time were 100%, 10.7 months and 12.3 months, respectively. KPS pre-surgery（68.8 ± 1.7） ; pos-surgery（90.8 ± 2. 3） ; the difference had a obvious statistic significance（t = 9.92, P〈0.01 ）. Conclusion： The pericardial window by video-assisted thoracoscopic surgery could improve effectively the life quality and prolong the survival time, which should be considered as the first choice in the treatment of refractory malignant pericardial effusion.

关 键 词：胸腔镜 恶性心包积液 

分 类 号：R542.12[医药卫生—心血管疾病]