阿片类物质在中枢神经系统的免疫调控作用  

Immunomodulatory Role of Opioids in the Central Nervous System

作　　者：盛文绚 胡树仙 赵忠君 

机构地区：[1]美国明尼阿波利斯医学研究基金会

出　　处：《生理科学进展》1998年第2期125-129,共5页Progress in Physiological Sciences

摘　　要：内源及外源性阿片具有调节神经元与胶质细胞的功能，这些调节具有保护或损伤脑功能的双重作用。吗啡具有促进爱滋病毒复制及继发感染的作用。另一方面，阿片受体中的ｋａｐｐａ受体可能具有保护神经元的作用。更深层次的研究应是了解阿片通过什么机制作用在胶质细胞和神经元上。Endogenous and exogenous opioids can influence and modulate neuronal and glial cell function via an opioid receptor mediated mechanism, leading to either protection or damage of the brain. Opiates such as morphine have been postulated to promote the progression of HIV1 and the development of secondary opportunistic infections. Kappa opioid receptor ligands, on the other hand, may play a neuroprotective role. More studies are needed to delineate how opioids exert their effects on glial cells as well as neurons with the goal of developing new therapeutic approaches for neurodegenerative disease.

关 键 词：阿片 受体 HIV 中枢神经系统 免疫调控 

分 类 号：R392.12[医药卫生—免疫学] R512.910.2[医药卫生—基础医学]