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出 处:《Chinese Medical Journal》2009年第4期459-459,共1页中华医学杂志(英文版)
摘 要:Background Lesions at coronary bifurcations always are a big challenge for interventionists even with the advent ofdrug eluting stents (DES).Even as more clinical trials are published,operators still can not confirm that one strategy ismore efficient than another.Selection of patients and short term follow-up contribute to the difficulty in comparingstrategies.Methods From April 2004 to April 2008,505 consecutive Chinese patients underwent DES implantation for truebifurcation lesions;including 258 using crush strategy (213 male,(56.7±10.8) years old) and 247 using no crush strategy(206 male,(58.1±10.1) years old) were analyzed.Results The follow-up period ranged from 237 to 1223 days,average (537±340) days for the crush group and(538±351) days for the no crush group.There was no significant difference of major adverse cardiac events (MACE) ratebetween the two groups (10.1% vs 12.1%;P=0.481),nor in cardiac death,nonfatal myocardial infarction (MI) or in thetarget vessel revascularization (TVR) (0.4% vs 1.6%;P=0.207,2.7% vs 2.8;P=1.000 and 7.0% vs 7.7%;P=0.865).Thestent thrombosis rate was similar in the two groups (1.6% vs 2.0%;P=0.409),late and very late stent thrombosis in bothgroups were very low (0.4% vs 0.4%;P=1.000).Seven-month angiographic follow-up showed no significant difference ofthe restenosis rate between the two groups (11.0% vs 13.5%;P=0.786).During the follow-up,cardiac death,nonfatal MI,TVR and ST free survival rate showed no significant difference between the two groups.The only variant identified as apredictor of MACE was percutaneous coronary intervention (PCI) in the first two years,which accounted for 47% ofpatients of all cases in four years.Conclusion Crush technique showed similar long-term clinical effect compared with other two DES techniques forcoronary bifurcation lesions,the surgeons’ skills are very important for reducing clinical events.
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