激活蛋白1及基质金属蛋白酶在急性心肌梗死后心脏组织中的表达  

The expression and significance of activator protein-1 and matrix metalioproteinases in the human heart post acute myocardial infarction

作　　者：谢双伦[1] 王景峰[1] 聂如琼[1] 袁沃亮[1] 李飞[1] 林永青[1] 

机构地区：[1]中山大学附属第二医院心内科,广州510120

出　　处：《中华内科杂志》2009年第3期205-207,共3页Chinese Journal of Internal Medicine

基　　金：国家自然科学基金（30770899）

摘　　要：目的观察激活蛋白-1（AP-1）、基质金属蛋白酶类（MMPs）在急性心肌梗死（AMI）患者心脏组织中的表达及意义。方法采用免疫组化技术分别检测AP-1亚单位c-Jun、MMP-2及MMP-9在人正常及AMI心脏组织中的表达。结果（I）正常心脏组织可少量表达c—Jun、MMP-2及MMP-9；在AMI心脏组织中c—Jun、MMP-2及MMP-9表达较正常心脏组织明显增加（P值均〈0．05）。（2）在AMI心脏组织中，MMP-9表达水平与c-Jun表达水平明显呈正相关（r=0．773，P〈0．01）。结论在AMI心脏组织中AP-1及MMPs表达均明显升高，提示AP-1转录激活及MMPs表达增加可能在AMI后心室重构中发挥重要的作用。Objective To investigate the expression and significance of activator protein-1 （ AP-1 ） and matrix metalloproteinases （MMPs） in acute myocardial infarction （AMI） subjects. Methods Immunohistochemical techniques were used to detect the subunit of AP-1 （ c-Jun）, MMP-2 and MMP-9 in human AMI and normal heart tissue and the expressions of c-Jun and MMPs were measured with computer image analysis system. Results （1） There were expressions of c-Jun, MMP-2 and MMP-9 in normal heart tissue, mainly in myocardial cells and cardiac fibroblasts, and their expressions in AMI myocardial tissues were all significantly higher than those in normal myocardial tissues （ P 〈 0.05 ）. （ 2 ） The level of MMP-9 expression was significantly and positively correlated with c-Jun in AMI heart tissue （ r = 0. 773, P 〈 0. 01 ）. Conclusions The expressions of AP-1 and MMPs increase in human myocardial infarction. These findings suggest that AP-1 transcription activation pathway and MMPs may play an important role in ventricular remodeling of myocardial infarction.

关 键 词：心肌梗死 基质金属蛋白酶类 转录激活因子-1 

分 类 号：R686[医药卫生—骨科学]