Na^+偶联单羧酸转运蛋白及其在药物转运中的作用  

Sodium-coupled monocarboxylate transporters and their actions in drug delivery

作　　者：许秋霞[1] 王寅[1] 马丽焱[1] 

机构地区：[1]中国医学科学院中国协和医科大学药用植物研究所,北京100193

出　　处：《中国临床药理学与治疗学》2009年第1期103-109,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家中医药管理局留学回国人员择优项目(国中医药函[2006]51号)

摘　　要：Na+偶联单羧酸转运蛋白(sodium-coupled monocarboxylate transporter,SMCTs)包括两种亚型:SMCT1和SMCT2。两者的底物特异性相似,但SMCT1对底物的亲和力比SMCT2高。在机体中,SMCT1和SMCT2表达于肠道、肾脏和视网膜并通过协同作用促进相应组织对单羧酸的转运,以维持机体的生理功能。本文从生物学特征、底物与抑制剂、组织分布与生理功能及其在药物转运中的作用等方面对SMCT1和SMCT2进行综述。Sodium-coupled monocarboxylate transporters contain two subtypes： SMCT1 and SMCT2. Both of them have similar substrate specificity, but SMCT1 has higher affinity for substrate than SMCT2. SMCT1 and SMCT2 are expressed in intestine, kidney and retina. They maintain physiological function of the tissues by transporting monocarboxylate cooperately. In this paper, the biological characteristics, substrates and inhibitors, tissue distribution and physiological function, as well as actions in drug delivery of SMCT1 and SMCT2 are reviewed.

关 键 词：Na^+偶联单羧酸转运蛋白 生物学特征 组织分布 生理功能 药物转运 

分 类 号：R969.1[医药卫生—药理学]