TCRβ链CDR3谱系与乙型肝炎病毒的感染  

CDR3 spectratyping of TCR beta chain and hepatitis B virus infection

作　　者：伍绍强[1] 姚新生[2] 林世德[1] 邱隆敏[1] 

机构地区：[1]遵义医学院附属医院感染科,563003 [2]遵义医学院免疫学教研室,563003

出　　处：《国际流行病学传染病学杂志》2009年第1期56-58,共3页International Journal of Epidemiology and Infectious Disease

基　　金：国家973计划（2308CB517310）;国家自然科学基金（30760231）;贵州省优秀科技教育人才省长专项基金[黔省专合字（2008）111号]

摘　　要：近年来，随着免疫扫描谱型分析技术的建立，T细胞受体互补决定N（TCRCDR）与HBV感染关系的研究取得了较大进展。通过对TCRCDR3谱型分析来研究HBV感染状态下克隆性和寡克隆性增生的T细胞，能进一步了解HBV感染后T细胞的免疫应答，指导疾病的免疫治疗，同时为后期T细胞表位疫苗的研制提供基础。此文就近年来TCRCDR3谱系与HBV感染的关系进行了综述。Recently, with the establishment of immunoscope spectratyping technique, great progress has been made in researching the relation between CDR3 of TCR beta chain （TCR CDR3） and HBV infection. Through the analysis of TCR CDR3.in clonal and oligoclonal expansion of T cell in patients with HBV infection, the roles of T cell immune response in HBV infection will be better understanding, so as to give some new ideas in the immunotherapy and the T cell epi-position vaccine development. Tne recent progress on TCR CDR3 genealogy in HBV infection is summarized in the article.

关 键 词：肝炎病毒 乙型 CDR3 免疫测定 

分 类 号：R51[医药卫生—内科学]