缺失型血管紧张素转换酶基因与心肌梗塞之间相关性的研究  

Insertion/Deletion Polymorphism in the Gene for Angiotensin Converting Enzyme in Patients with Myocardial Infarction

作　　者：姚晓苓[1] 汪家瑞[1] 白丹[1] 曹心民[1] 

机构地区：[1]北京宣武医院心内科,北京100053

出　　处：《心肺血管病杂志》1998年第2期95-97,共3页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：本文采用PCR技术对91例心肌梗塞患者及132例正常对照者的血管紧张素转换酶（ACE）基因插入／缺失多态进行检测，结果显示：心肌梗塞组ACE基因中缺失型（DD型）分布（30％）明显高于正常对照组（17％）P＜0．05；心肌梗塞组缺失型等位基因频率（0.495）也明显高于对照组（0．356）P＜0．05。结果表明：缺失型ACE基因多态可能是中国人心肌梗塞的一个危险因素。It was reported that the insertion/deletion polymorphism of the angiotensin - converting enzyme (ACE) gene was associated with serum ACE level and proposed as an independent risk factor for the myocardial infarction (MI) in the Caucasian population. This study was designed to investigate the correlation of the ACE I/D polymorphism with MI in Chinese population. A 287 - bp I/D polymorphism in intro 16 of the ACE gene was determined by polymerase chain reaction in 132 healthy subjects and 91 patients with MI. The frequencies of D allele (0. 495) and DD genetype (0. 30) were higher in the MI group than those in the control subjects (0. 356 and 0. 17,P<0. 05). Conclusion: Deletion polymorphism of the ACE gene may be an important risk factor of MI in Chinese population.

关 键 词：基因 多态性 心肌梗塞 ACE 

分 类 号：R542.22[医药卫生—心血管疾病]