乙肝患者的肝细胞损害与IL-8和HSS的关系  

Relationship between hepatocellular injury and IL-8,HSS in patitent with hepatitis B

作　　者：陈智平[1] 

机构地区：[1]广西医科大学流行病学教研室

出　　处：《广西预防医学》1998年第2期68-70,共3页Guangxi Journal of Preventive Medicine

摘　　要：为研究乙肝患者的肝细胞损害与白细胞介素８（ＩＬ－８）及肝细胞刺激物质（ＨＳＳ）的关系，本文应用ＥＬＩＳＡ法检测１７７例乙肝患者血清的ＩＬ－８和ＨＳＳ含量。结果显示：乙肝患者血清的ＩＬ－８和ＨＳＳ水平均较对照组明显升高（Ｐ＜０．０５），且分别与血清ＡＬＴ水平密切相关（Ｐ＜０．０５），而血清ＩＬ－８和ＨＳＳ含量亦存在相关关系（Ｐ＜０．０５）。揭示ＩＬ－８和ＨＳＳ可能相互影响，并在肝病患者的肝细胞损害。To study the relationship between hepatocellular injury in hepatitis B patient and hepatocyte stimulator substance,HSS)、interleukin-8(IL-8),enzyme linked immunohistochemical assay(ELISA)was performed in 177 patients with hepatitis B to determine the serum levels of IL-8 and HSS.Results showed that IL-8 and HSS levels in serum of hepatitis B patients increased significantly as compared with normal subjects(P<005),moreover,the contents of IL-8 and HSS correlated closely with the serum levels of ALT(P<005).There was a close relationship between the serum levels of IL-8 and HSS.The results suggest that IL-8 and HSS may be affected eath other and play an important role in process of hepatic injury,repair and regeneration.

关 键 词：乙型肝炎 白细胞介素8 肝细胞刺激物质 

分 类 号：R512.62[医药卫生—内科学]