自发性狼疮小鼠模型研究进展  

Advances of spontaneous lupus-prone mouse model

作　　者：余立凯[1] 黄安斌[1] 侯晓华[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院风湿免疫科,武汉430022 [2]华中科技大学同济医学院附属协和医院消化科,武汉430022

出　　处：《国际病理科学与临床杂志》2009年第1期82-85,共4页Journal of International Pathology and Clinical Medicine

摘　　要：自发性狼疮小鼠模型的研究对于探索人类系统性红斑狼疮的病因、发病机制和治疗有重要意义。目前研究较充分的有BXSB/MpJ,NZB/W.F1和MRL/lpr三种品系的自发性小鼠模型,其来源和遗传学、临床与组织学特征、自身抗体等有各自的特点。Research on spontaneous lupus-prone mouse model is important for the exploration of the causes, pathogenesis and treatment of systemic lupus erythematosus in human being. There have been more studies mainly on spontaneous mouse model BXSB / MpJ, NZB/W. F1 and MRL / lpr three strains in recent years. The source and genetics, clinical and organizational characteristics, autoantibodies, abnormal immune cells and experimental treatment of three strains have respective characteristics.

关 键 词：红斑狼疮 小鼠 模型 

分 类 号：R593.241[医药卫生—内科学] R-332[医药卫生—临床医学]