补脑丸对动物学习记忆的影响  

Influence of Bunao Pill on the Learning and Memory of Rats and mice

作　　者：马志义[1,2] 王秉文[1,2] 刘冬平[1,2] 吴英[1,2] 

机构地区：[1]西安医科大学基础医学院药理学教研室 [2]西安医科大学药学院药理学教研室

出　　处：《中药新药与临床药理》1998年第1期35-36,共2页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：研究补脑丸对小鼠及大鼠学习、记忆的影响。小白鼠避暗法的试验结果表明，补脑丸０．６５ｇ（生药量）／ｋｇ及１．２９ｇ（生药量）／ｋｇ灌胃，连续７ｄ，均能显著延长氢溴酸东莨菪碱所致记忆获得障碍小鼠测试时的潜伏期，补脑丸１．２９ｇ（生药量）／ｋｇ还能显著减少氢溴酸东莨菪碱所致记忆获得障碍小鼠测试时５ｍｉｎ内的错误次数。结果提示，补脑丸能明显改善东莨菪碱所致记忆获得障碍小鼠的记忆功能。大白鼠跳台法的实验结果表明，补脑丸０．３６ｇ（生药量）／ｋｇ及０．７２ｇ（生药量）／ｋｇ灌胃，连续１０ｄ，均能延长测试时的潜伏期及减少测试时５ｍｉｎ内错误次数，提示补脑丸能增强大白鼠的记忆功能，补脑丸０．７２ｇ（生药量）／ｋｇ还能减少训练时５ｍｉｎ内的错误次数。Influence of Bunao Pill (BNP) on the learning and memory of rats and mice was studied. Oral administration of BNP in dosages of 0.65g /kg and 1.29g/kg for 7 consecutive days significantly lengthened the latent period of acquired memory disturbance induced by scopolamine hydrobromide in mice, and that in dosages of 0.36g/kg and 0.72g/kg for 10 consecutive days also lengthened the latent period and decreased the times of error within 5 minutes in rats. It is suggested that BNP can improve the memory of mice and the learning ability of rats.

关 键 词：补脑丸 药理学 学习 药物作用 记忆 

分 类 号：R289.5[医药卫生—方剂学] R285.5[医药卫生—中药学]