新型缓释LNG-Cu-IUD在人体外及体内的药物释放研究  

STUDY ON DRUG RELEASING OF NEW TYPE OF LNGCUIUD

作　　者：张杰[1] 张娜[1] 彭敦仁[1] 王江[1] 

机构地区：[1]天津市计划生育研究所药理室

出　　处：《天津医科大学学报》1998年第1期19-20,共2页Journal of Tianjin Medical University

基　　金：八五攻关课题

摘　　要：目的：主要检测铜药复合型ＩＵＤｓ中ＬＮＧ在体内外长期释放的稳定性。方法：在体外释放介质中连续测定药物释放一年，测得平均日释放量为６．２３±０．２２μｇ。在稳态释放阶段药物释放速率是一个常数。铜材溶蚀对药物释放没有影响。２１名带器３０天至５４０天的志愿受试者，经节育器ＬＮＧ残留量分析。结果：在稳态释放阶段平均日释放量为６．９８±１．９４μｇ／ｄａｙ，与体外ＬＮＧ释放特征基本相同。结论：释放率检验证明节育器中ＬＮＧ在体内外的释放率是稳定的，符合设计要求。Objective:The purpose to determine stability of LNG releasing of LNG-Cu-IUD in vivo and in vitro Methods:The average releasing rate of LNG at medium for a year was 623±022ug/day During steady releasing state,releasing rate of LNG was a constant Corrosion of copper from devices did not interfere drug releasing 21 of volunteers were involved in this study for 540 days By the method of remnant LNG analysis, the average steady state releasing rate per day was 698ug/day±194ugResults: The characteristics of drug releasing were similar in vivo and in vitro Conclusions:It is concluded that the releasing rate of LNG in vivo and in vitro is stable and accords with demands of experimental design

关 键 词：释放速率 宫内节育器 体外及人体内 

分 类 号：R169.41[医药卫生—公共卫生与预防医学] R979.21