脾气虚大鼠肝细胞超微结构动态变化的实验研究  

Experimental Study on Ultrastructure of Hepatic Cells of Rat Models of Spleen-deficiency

作　　者：刘健[1] 刘春丽[1] 方朝晖[1] 胡闻[2] 

机构地区：[1]安徽中医学院附属医院内科,合肥230031 [2]安徽省立医院电镜室,合肥230001

出　　处：《中国中西医结合脾胃杂志》1998年第1期32-33,共2页

基　　金：安徽省自然科学基金!95-医-17

摘　　要：用过劳及饮食失节法塑造大鼠脾气虚模型、结果表明，随着造模时间的延长，脾气虚大鼠肝细胞线粒体的肿胀、基质变浅、空泡变淡、嵴断裂及排列紊乱等逐渐加重，同时空肠细胞线粒体也有类似变化。提示脾气虚大鼠肝细胞线粒体的变化是一个由轻到重的渐进过程，其病变程度与空肠细胞线粒体的病变程度密切相关；随着营养物质吸收障碍的逐渐加重，肝细胞线粒体的病变程度也渐趋严重，肝脏合成血浆蛋白的能力逐渐下降，是脾气虚证低蛋白血症逐渐加重的形态学基础和发病机制。The spleen-qi-deficiency rat models were induced by overstrain and improper dieting. The swelling, matrixes shallowing, vacuolar degeneration, breakage and derangement ofhepatic cell mitochondria (HCM ) were aggravated over time. The mitochondria of jejunum(MOJ ) showed similar change as HCM. The results showed that pathologic changes of HCM inspleen dericiency rats was closely associated with the change of MOJ. With the aggravation ofdysfunction of absorption of nutritive substances, the ability of liver cells to synthesize plasmaproteins was gradually impaired and the pathologic changes of HCM also worsen. These are thepathologic mechanism of hypoalbuminemia of patients with spleen-qi deficiency.

关 键 词：脾气虚 肝细胞线粒体 超微结构 空肠细胞线粒体 

分 类 号：R256.302[医药卫生—中医内科学]