常用抗癫痫药对大鼠胚胎毒性的比较  

A Comparition of the Embryotoxicity of Antiepileptic Drugs in Rats

作　　者：王维平[1] 龚淑英[1] 李春岩[1] 刘登会[2] 

机构地区：[1]河北医科大学第二医院神经内科,050000 [2]石家庄铁路中心医院神经内科

出　　处：《脑与神经疾病杂志》1998年第2期72-75,共4页Journal of Brain and Nervous Diseases

摘　　要：对临床常用的三种抗癫痫药(AEDs)苯妥英钠(PHT)、丙戊酸内(VPA)和卡马西平(CBZ)进行胚胎毒性的比较,以期找到一种胚胎毒性较低的AEDs。用人类平均治疗量的10倍AEDs给予怀孕母鼠。孕末时,对其胎鼠进行胚胎毒性的鉴定。PHT组除了上枕骨骨化程度低于对照组外,未见其它胚胎毒性。VPA和CBZ组的胚胎毒性高于对照组。VPA组又高于CBZ组。VPA胚胎毒性最强,CBZ次之,PHT最弱。The experiment was designed to compare the effects of antiepileptic drugs (AEDs) phenytoin (PHT), valproate (VPA) and carbamazipine (CBZ) on inducing embryotoxicity in rats, and see whether any clear order of the embryotoxicity would emerge. Dams were given an AED respectively at 10 times the humman the rapeutic dose. The fetuses were examined at pregnant day 20. PHT did not have toxicities for rat's fetuses except that ossification of supraoccipital bone delayed. The emryotoxicity of VPA and CBZ were severer significantly than the control. VPA's was severer than CBZ's. VPA was the toxicest of three AEDs for rat's fetuses. CBZ took secondary place. PHT was the slightest.

关 键 词：抗癫痫药 大鼠 胚胎毒性 药理 

分 类 号：R971.6[医药卫生—药品]