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作 者:徐瑞俊[1] 刘忠权[1] 陈国根[1] 郭丰涛[1] 何南章[1] 王腾蛟[1] 唐志文[1] 王云景[1]
机构地区:[1]海军医学研究所
出 处:《中华航海医学杂志》1998年第1期3-6,共4页
摘 要:目的:探讨氨(NH3)、汽油(CxHy)、三氯-氟甲烷(F11)和氯仿(CHCl3)复合作用规律及其主因素。方法:用多因素、多水平的正交实验设计方法,进行上述4种气体的复合实验研究,指标包括呼吸、遗传、血液和血气类共23项。用三水平四因素方差分析程序进行主因素分析。结果:4种气体的联合作用对呼吸有明显抑制作用,多数实验组对免疫有抑制作用,随着NH3浓度增大,引起呼吸性碱中毒合并代谢性酸中毒。多数指标的方差分析表明,影响指标改变的主因素是NH3,其次为CxHy,F11和CHCl3仅是个别指标变化的主因素。结论:在4种气体的联合作用下,NH3是影响指标改变的最主要因素,为了保障艇员的健康。Aim: To explore the rule and determine the principal factor of the combined effects of NH3,CxHy, F11 and CHCl3. Methods: Orthogonal design method was used for this 4 gases combined experiment. Changes of 23 parameters including respiratory, hereditary, blood and bloodgas indexes were observed. The principal factor of the combined effect was determined by analysis of variance(ANOV). Results: Breathing was evidently inhibited by the combined effect of the 4 gases; and immunity function was depressed in most of the experimental groups. Respiratory alkalosis accompanied with metabolic acidosis was induced along with the increasing of NH3 concentration. ANOV showed that the principal factor of the combined effect was NH3. The second factor was CxHy with F11 and CHCl3 next. Conclusion: NH3 is the principal factor causing the changes of index parameters in the 4 gases combined experiment. It is suggested that the concentration of NH3 should be controlled for the health of the ship personnel.
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