肝移植手术后并发毛霉菌属医院感染的临床分析  

Complicated Hospital Infection by Mucor in Liver Transplant Recipients:A Clinical Analysis

作　　者：李爱民[1] 曹力[2] 赵海平[1] 

机构地区：[1]武警总医院手术室,北京100039 [2]武警总医院感染控制科,北京100039

出　　处：《中华医院感染学杂志》2009年第6期697-698,共2页Chinese Journal of Nosocomiology

摘　　要：目的调查肝移植术后患者医院内毛霉菌属感染的发生率、临床表现及其预后。方法对医院的肝移植手术患者术后所有发生毛霉菌属感染的病历资料进行回顾性调查研究。结果750例肝移植患者手术中共发生毛霉菌属感染8例,发生率为1.1%,其中手术切口感染6例,表现为伤口延迟不愈及迅速增多的表面分泌物;经抗真菌治疗后均痊愈,肺部毛霉菌属感染2例,表现为与其他细菌的混合性肺部感染,该两例并发多器官衰竭而死亡。结论肝移植术后的毛霉菌属感染最常见的表现为切口感染,患者均获得治愈,而并发肺部毛霉菌属感染者治疗困难,其预后极差。OBJECTIVE To investigate the incidence, symtoms and prognosis of hospital infection by Mucor after liver transplantation. METHODS The clinical data of all the patients with complicated hospital infection orthotopic by Mucor after orthotopic liver transplantation were analyzed restrospectively. RESULTS There were 9 cases with complicated hospital infection by Mucor from in 750 liver transplant recipients. Seven cases developed superficial incisional infection with delayed healing and rapid increased secretion on the surface of incisions. All of them recovered after antifungal therapy. Two cases had pulmonary Mucor infection combined with bacteria and died of multi-organ failure. CONCLUSIONS The incidence of hospital infection by Mucor in liver transplant recipients is about 1% The most common symtoms are superficial incisional infection and the patients recover well. However, the cases with complicated pulmonary Mucor infection are difficult to treat and have a poor prognosis.

关 键 词：肝移植术 医院感染 毛霉菌属 

分 类 号：R379[医药卫生—病原生物学]