NIR技术对复方丹参提取过程的在线监控研究  

On-Line quality control of Compound Danshen′s extracting process by NIR

作　　者：刘岩[1] 张延莹[1] 张金巍[1] 张爱军[1] 

机构地区：[1]天津天士力现代中药资源有限公司,天津300410

出　　处：《中草药》2009年第3期383-386,共4页Chinese Traditional and Herbal Drugs

基　　金：国家科技支撑项目(2007BAI47B02)

摘　　要：目的利用NIR技术研究并建立复方丹参有效成分的检测模型，实现生产规模复杂中药体系提取过程的在线质量监控。方法在提取装置上在线采集提取液的近红外光谱，同时进行丹参素的HPLC检测，采用偏最小二乘法建立丹参素的质量浓度检测模型。结果最佳建模波段为9715～7082cm^-1，模型相关系数（R）为0．9594，校正均方差（RMSEC）为0．0494，预测值与真实值的平均相对误差为7．2％。结论利用NIR技术能够实现生产规模复方丹参提取过程的在线质量监控。Objective To research and develop a model of the representative active component＇s content by NIR spectroscopy, so as to realize the on-line quality control of extracting process for multiple herbal medicine system in product scale. Methods The on-line NIR detection of extracting process was used to obtain the NIR spectrum, HPLC detection of the extracts was carried out to determine the content of danshensu, and PLS method was used to establish the relationship between the information of NIR and HPLC. Results The optimum NIR wavelength range was 9 715-7 082 cm^-1, R=0. 959 4, RMSEC= 0. 049 4, the average relative error was 7.2%. Conclusion NIR Technique could be used in the on-line quality control of Compound Danshen＇s extracting process.

关 键 词：复方丹参 近红外技术 在线质量监控 高效液相色谱法 

分 类 号：R284.2[医药卫生—中药学] R286.02[医药卫生—中医学]