聚乙二醇改性甘草次酸/5-氟尿嘧啶复合物的制备与生物活性研究  

Preparation and bioactivity of glycyrrhetinic acid-polyethylene glycol/5-fluorouracil complexes

作　　者：何玉凤[1] 张慧芳[1] 宋精锋[1] 王荣民[1] 丁兰[2] 

机构地区：[1]西北师范大学甘肃省高分子材料重点实验室,甘肃兰州730070 [2]西北师范大学生命科学学院,甘肃兰州730070

出　　处：《西北师范大学学报（自然科学版）》2009年第2期61-64,共4页Journal of Northwest Normal University(Natural Science)

基　　金：教育部新世纪优秀人才支持计划资助;教育部重点基金资助项目(207120);甘肃省自然科学基金资助项目(3ZS061-A25-036)

摘　　要：将甘草次酸用聚乙二醇（PEG）改性后，合成了两种聚乙二醇改性甘草次酸的5-氟尿嘧啶复合物．采用红外光谱和核磁氢谱对其进行了结构表征，用SRB法对制得的复合物进行了肿瘤细胞毒活性评价．结果表明，系列化合物均对人体肝癌细胞Bel-7402有较强的抑制生长活性，IC50值均小于100mg·mL^-1，在10～50mg·mL^-1范围内，是一类具有应用前景的抗肿瘤药物前体．Using polyethylene glycol to modify glycyrrhetinic acid, two kinds of derivatives of 5- fluorouracil are synthesized. They are characterized by IR spectra and ^1HNMR spectra. The antitumor activities of the complexes are studied by SRB assay. It indicates that the polymer modified with 5- fluorouracil shows high inhibition to tumor cell Bei-7402 growth activity and the IC50 of the complexes are between 10 mg·mL^-1 and 50 mg·mL^-1 which are all lower than 100 mg·mL^-1. It shows that the compounds possess good antitumor activity against liver cancer cell in vitro.

关 键 词：甘草次酸 5-氟尿嘧啶 抗肿瘤细胞活性 

分 类 号：O626.41[理学—有机化学]