局灶性脑缺血再灌注模型大鼠脑SOD和MDA的变化  

CHANGES OF SOD AND MDA IN BRAIN OF FOCAL CEREBRAL ISCHEMIA-REPERFUSION MODEL RATS

作　　者：郑晓影[1] 赵淑敏[1] 陈萌[1] 李涵 

机构地区：[1]承德医学院,河北承德067000 [2]承德市解放军第266医院

出　　处：《承德医学院学报》2009年第1期12-14,共3页Journal of Chengde Medical University

基　　金：河北省科技厅资助项目(07276101D-46)

摘　　要：目的:观察局灶性脑缺血再灌注大鼠模型脑超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的变化。方法:用线栓法建立大鼠局灶性脑缺血再灌注模型,TTC染色显示梗死范围;测定再灌注损伤脑组织中SOD活性和MDA含量。结果:与假手术组相比,模型组脑组织SOD活性显著降低、MDA含量明显增加(P<0.01)。结论:局灶性脑缺血再灌注能显著降低再灌注损伤脑组织SOD活性,增加MDA含量。Objective:To observe the changes of superoxide dismutase(SOD)and malondialdehyde(MDA) in brain of focal cerebral ischemia-reperfusion model rats.Methods:The focal cerebral ischemia-reperfusion model rats were established by suture embolic method.TCC was used to display infraction scope;the SOD activity and MDA content in reperfusion injury brain were measured.Results:Compared with control group,in focal cerebral ischemia-reperfusion rats model brain,the SOD activity decreased and MDA content increased obviously(P<0.01).Conclusions:Focal cerebral ischemia-reperfusion can obviously decrease SOD activity and increase MDA content in reperfusion injury brain.

关 键 词：线栓法 SD大鼠 局灶性脑缺血再灌注 SOD MDA 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]