抗结核药物联合蜂蜡巴豆治疗耐药肺结核的疗效观察  

The Observation of Clinical Effect of Anti-tuberculosis Drugs Combined with Beeswax Croton in Treatment of Drug-resistant Tuberculosis

作　　者：卢俊敏[1] 赵中夫[2] 

机构地区：[1]山西医科大学,030001 [2]长治医学院肝病研究所

出　　处：《长治医学院学报》2009年第1期21-23,共3页Journal of Changzhi Medical College

基　　金：山西省高校科技研究开发项目(200154)

摘　　要：目的:抗结核药物联合蜂蜡巴豆治疗耐药肺结核的临床疗效观察。方法:97例耐药患者入选,随机分配为A、B两组,A组47例,化疗联合蜂蜡巴豆;B组50例,单纯化疗。两组疗程均为18个月。结果:痰菌阴转率:治疗3个月末,A组60.87%,B组30.43%(P<0.05),疗程结束时A组为84.8%,B组65.2%(P<0.05)。A组病灶有效变化率为91.30%,B组为73.91%(P<0.05)。虽然两组的病情好转情况无显著差异(P>0.05),但A组不良反应发生率显著低于B组(P<0.01)。结论:抗结核药物联合蜂蜡巴豆治疗耐药肺结核患者,对耐药结核有良好的治疗效果,并可减少化疗药物引起的毒副反应。Objective ：To observe the clinical effect of anti -tuberculosis drugs combined with beeswax croton in treatment of drug - resistant Tuberculosis. Methods ： 97 cases of multi - drug resistant tuberculosis randomly divided into two groups. In A group, 47 cases treated with antituberculosis drugs combined with beeswax croton. In B group,50 cases treated with antitubereulosis drugs alone. The course of treatment was 18 months.Results：At 3 months, the sputum negative conversion rate to group A and B was separately 60.87% and 30.43% （P 〈 0.05）. At the end of the course,it was 84.8% and 65.2% respectively （ P 〈 0.05）. The improvement rate of focal absorption was 91.30% and 73.91%, respectively（ P 〈 0.05）. Although there was no significant difference between group A and group B in improvement rate of disease（ P 〉 0.05）,the incidence of adverse reaction was lower in A group（ P 〈 0.01）. Conclusion： Anti -tuberculosis drugs combined with beeswax croton in treatment of drug - resietant Tuberculosis show a better therapeutic effect and also reduce anti - tuberculosis drugs toxic side effects.

关 键 词：蜂蜡巴豆 联合 肺结核 耐药 

分 类 号：R521[医药卫生—内科学]