小干扰RNA介导的多靶点肿瘤治疗  

Small interfering RNA mediated multi-target therapy of cancer

作　　者：邵荣光[1] 

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,北京100050

出　　处：《药学学报》2009年第3期219-225,共7页Acta Pharmaceutica Sinica

基　　金：国家重点基础研究发展计划(973计划)资助项目(2009CB521807);国家自然科学基金资助项目(30772583);教育部博士点基金资助项目(20070023017)

摘　　要：在各种不同的肿瘤中估计有多达数百个基因失调,但大多数肿瘤治疗是针对单癌基因。近来,肿瘤治疗模式发生了变化,已开始思考从单靶点治疗向多靶点治疗转变。有相当多的证据表明,多靶点治疗比单靶点治疗有较高的成功可能性,多靶点治疗将是今后最有吸引力的肿瘤治疗策略。本文综述了小干扰RNA在多靶点肿瘤治疗中的作用。It has been reviewed that as many as hundreds genes are dysregulated in various kinds of cancers, yet most therapies are targeted toward a single gene. Recently, the mode of cancer treatment has been changed by a shift in thinking from mono-target to multi-target therapies. There is considerable evidence that these have a higher possibility of success than mono-target therapy, and multi-target therapy should remain the most attractive avenue for future treatment strategies. In this article, we attempt to provide evidence for the role of small interfering RNA in multi-target therapy of cancer.

关 键 词：小干扰RNA 基因沉默 多靶点 增效作用 肿瘤治疗 

分 类 号：R963[医药卫生—微生物与生化药学]