冠心病患者血浆内脂素水平的初步研究  

Detection of Visfatin Level of Plasma in Patients with Coronary Artery Diseases

作　　者：付华[1] 祝烨[1] 游桂英[1] 刘小菁[2] 

机构地区：[1]四川大学华西医院心内科,成都610041 [2]四川大学华西医院心血管疾病研究室

出　　处：《四川大学学报（医学版）》2009年第2期322-324,共3页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(批准号30470437;30870596);四川省科技厅项目(2008FZ0156);成都市科技局项目(【2008】10号)资助

摘　　要：目的比较冠心病患者和正常人血浆中内脂素(visfatin)水平,并评价血浆visfatin水平与冠脉病变程度的相关关系。方法对48例冠心病患者(均接受冠脉造影确诊)及41例健康志愿者抽血测定血浆内脂素水平,并进行比较。同时记录冠心病患者冠脉病变支数及Gensini冠脉病变积分,与血浆内脂素水平进行相关性分析。结果冠心病组血浆内脂素水平为(28.58±14.53)ng/mL,对照组血浆内脂素水平为(16.01±6.09)ng/mL,冠心病组明显高于对照组,两组比较有统计学差异(P<0.01)。血浆内脂素水平与冠脉病变支数呈正相关(r=0.762,P<0.01);与Gensini冠脉病变积分呈显著正相关(r=0.906,P<0.01)。结论检测血浆内脂素水平有助于冠心病的早期诊断;血浆内脂素水平越高,冠脉病变程度越严重。Objective To study the plasma visfatin level in patients with coronary artery disease （CAD） and evaluate the correlation between plasma visfatin level and coronary lesion severity. Methods The level of plasma visfatin of 48 patients with CAD （proved by angiography） and 41 normal controls were detected and compared. Plasma visfatin was determined by an enzyme immunoassay. The lesion severity of coronary arteries was assessed by Gensini coronary scoring system, and the correlation between plasma visfatin level and coronary lesion severity was evaluated. Results Plasma visfatin level in the CAD group was significantly higher than that in the control group [（28.58± 14. 53） ng/mL vs （16. 01 ± 6. 09） ng/mL, P〈0. 01）. A significant positive correlation was found between coronary lesion severity score and Plasma visfatin level （r=0. 906,P〈0.01）. Conclusion Plasma visfatin level may be related to the pathogenesis of CAD. Detection of plasma visfatin might be helpful for early diagnosis of CAD, and patients with higher Plasma visfatin level may have more severe coronary lesion.

关 键 词：冠心病 内脂素 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]