细胞因子在动脉粥样硬化中的作用及临床应用进展  

The Role of Cytokines and its Advance of Clinical Applications in Atherosclerosis

作　　者：邵紫韫[1] 彭毅[2] 

机构地区：[1]中国人民解放军广州军区武汉总医院科训科,湖北武汉430070 [2]中国人民解放军广州军区武汉总医院心内科,湖北武汉430070

出　　处：《中国慢性病预防与控制》2009年第1期101-104,共4页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：动脉粥样硬化是血管壁的慢性炎症性疾病,作为炎症介质的细胞因子在动脉粥样硬化的发生发展中具有重要的意义。研究发现,多种细胞因子及其相关信号通路均参与了动脉粥样硬化的发生和发展,说明细胞因子在动脉粥样硬化疾病中具有良好的临床应用前景。研究表明,部分细胞因子可以作为动脉粥样硬化疾病的生物学标志,为早期诊断疾病、判断临床血管事件风险提供了良好的依据。研究者们还在靶向于细胞因子及相关信号通路的治疗方法上取得了重大的进展,为动脉粥样硬化的治疗开创了新的思路。对细胞因子在动脉粥样硬化中的作用及临床应用进展作一综述。Atherosclerosis is a chronic inflammatory disease of the vascular walls. As the essential mediators of inflammation, cytokines play important roles in atherosclerosis. Through widespread and penetrating studies, many cytokines, such as TNF-, IL-1, IL-6 and IFN-, are found involved in the development of atherosclerosis, as well as the related signal transduction pathways such as the NF- B pathway, the JNK/AP-1 pathway, and the JAK/STAT pathway. This implies that cytokines have a favorable perspective of clinical application. A few cytokines are identified as biomarkers, which help the early diagnosis of the disease and estimation of the risk of the clinical vascular events. Meanwhile, great progress has been made on the cytokine-targeted treatment of atherosclerosis, providing a novel therapy in the treatment of the disease.

关 键 词：细胞因子 动脉粥样硬化 信号转导通路 生物学标志 治疗 

分 类 号：R543.5[医药卫生—心血管疾病]