外源生长激素对运动大鼠循环ghrelin和IGF-Ⅰ水平的影响  

The Effects of Growth Hormone Administration on the Circulation Level of ghrelin and IGF-Ⅰ of the Trained Rats

作　　者：周刚[1] 丁树哲[2] 卢健[2] 许豪文[2] 

机构地区：[1]湖南大学体育学院,湖南长沙410082 [2]华东师范大学体育与健康学院,上海200062

出　　处：《北京体育大学学报》2009年第1期65-67,共3页Journal of Beijing Sport University

摘　　要：观察了短期注射重组人生长激素(rhGH)对大鼠GH/IGF-Ⅰ轴上相关物质的影响。方法:将32只SD雄性大鼠分为4组:对照组、运动组、GH组和GH+运动组,运动方式为游泳训练。在实验的最后一周给GH组和GH+运动组大鼠注射rhGH,持续7 d,1次/d,注射剂量为100μg/只。检测大鼠血液GH、ghrelin和IGF-Ⅰ浓度。结果:与对照组相比,短期注射rhGH后,大鼠血浆ghrlin浓度明显下降(P<0.01),血清IGF-Ⅰ浓度显著上升(P<0.01),血液IGF-Ⅰ/ghrelin比值明显增大。结论:1)短期注射rhGH使血浆ghrelin浓度降低,提示外源GH对ghrelin有负反馈调节作用;2)验证了前人的发现,使用外源GH可明显提升大鼠血清IGF-Ⅰ水平。the research focuses on the effects of short-term injection of recombinant human GH on the relational elements in GH/IGF-Ⅰ axis of trained rots. Methods： 32 rats are divided randomly into 4 groups： control group, exercise group, GH group and GH plus exercise group. The exercise pattern is swimming. Rats in GH and GH ＋ exercise group are injected with rhGH in the last week of the experiment, which lasts 7 days consecutively, one single injection with a dose of 100μg for each rat each day. Afterwards the blood GH, ghrelin and IGF-Ⅰ level are detected. Results： Compared with control group, after having been injected with rhGH for a short term, the plasma ghrelin level reduces remarkably （ P 〈 0.01 ）, serum IGF-Ⅰ increases markedly （ P 〈 0.01 ）, and the rate of hlood IGF-Ⅰ/ghrelin increases markedly in rots. Conclusions： 1 ） Short-term rhGH administration reduces plasma ghrelin level, which indicates the negative feedback regulatory effect of GH administration on blood ghrelin level. 2） Prior discoveries have been testified that serum IGF-Ⅰ can be increased markedly by GH administration.

关 键 词：生长激素 GHRELIN 胰岛素样生长因子1(IGF-Ⅰ) 运动 

分 类 号：R87[医药卫生—运动医学]