早期应用rhu-EPO对早产儿神经行为发育的影响  

Early use of recombinant human erythropoietin promotes neurobehavioral development in preterm infants

作　　者：何金水[1] 黄仲玲[1] 杨鸿[1] 翁开枝[1] 朱少波[1] 

机构地区：[1]福建医科大学附属漳州市医院新生儿科,福建漳州363000

出　　处：《中国当代儿科杂志》2008年第5期586-588,共3页Chinese Journal of Contemporary Pediatrics

摘　　要：目的评价重组人类基因促红细胞生成素(rhu-EPO)对早产儿神经行为发育的影响。方法对44例早产儿(男30例,女14例)随机分为对照组、rhu-EPO治疗组,每组各22例,治疗组于生后第7天予rhu-EPO治疗4周,所有早产儿于纠正胎龄40周行新生儿行为神经检测(NBNA),生后6,12月用Gesell量表法进行神经发育评价。结果①治疗组NBNA评分36.20±0.75分,高于对照组的34.40±1.05分(P<0.05);②治疗组Gesell发育量表在生后6月,治疗组精细动作的发育商高于对照组,在生后12月治疗组有3个能区(即大运动、精细动作和语言能区)的发育商高于对照组,差异有统计学意义(P<0.05)。结论早期应用rhu-EPO可促进早产儿神经行为的发育。Objective To evaluate the effect of the early use of recombinant human erythropoietin （rhu-EPO） on neurobehavioral development in preterm infants. Methods Forty-four preterm infants （30 males and 14 females ） were randomly divided into two groups ： Rhu-EPO treatment and untreated control （ n = 22 each）. From postnatal day 7, the Rhu-EPO treatment group received intravenous rhu-EPO （250 IU/kg,3 times weekly） for 4 weeks. A Neonatal Behavioral Neurological Assessment （NBNA） was performed at 40 weeks of corrected gestational age. A Gesell Development Schedule was used to evaluate neurological development 6 and 12 months after birth. Results The NBNA score in the rhu-EPO treatment group （36.20 ± 0.75 ） was significantly higher than that in the control group （ 34.40 ± 1.05 ） at 40 weeks of corrected gestational age （ P 〈 0.05 ）. The developmental quotient of fine motor in the rhu-EPO treatment group was significantly higher than that in the control group 6 months after birth （ P 〈 0. 05 ）. By 12 months after birth, the developmental quotient of gross motor, fine motor and language in the rhu-EPO treatment group was significantly higher than that in the control group （ P 〈 0.05 ）. Conclusions Early use of Rhu-EPO can promote neurobehavioral development in preterm infants.

关 键 词：促红细胞生成素 神经发育 新生儿神经行为评定 GESELL发育量表 早产儿 

分 类 号：R722.6[医药卫生—儿科]