紫外线诱导皮肤光老化的形成机制  

Ultraviole induced formation mechanism of photoaging

作　　者：李春雨[1] 张丽宏[1] 张宁[2] 杨智荣[2] 

机构地区：[1]黑龙江中医药大学佳木斯学院美容学科 [2]黑龙江中医药大学佳木斯学院中医美容研究所,黑龙江佳木斯154007

出　　处：《中国美容医学》2009年第3期416-419,共4页Chinese Journal of Aesthetic Medicine

基　　金：黑龙江省自然科学基金(编号:D2005-24)

摘　　要：光老化是人体暴露部位皮肤衰老的主要原因,其机理的阐明对防护皮肤衰老及治疗光损性疾病具有十分重要的意义。本文总结了近些年该领域的研究成果,发现日光中的UV主要通过损伤DNA、进行性蛋白质交联、降低免疫应答、产生高度反应自由基损伤细胞和组织等机制造成皮肤光老化。UVB和UVA在诱导皮肤光老化形成中,既有各自的特点,又相互协同,而UVA单独对真皮深层的穿透能力及对真皮组织的损伤机制尚待进一步研究。Photoaging is the primary factor of skin aging to exposed parts of the body.Its mechanism is of great significance to prevent skin aging and treat light-induced disease. This article summed up the research results of this field,found that solar ultraviolet radiation induced photoaging mainly through DNA damage, progress of protein crosslinks, reducing the immune response, having a high degree of reaction of free radicals to damage cells and tissues. Inducing the formation of photoageing, though there is synergies between UVB and UVA, they both have their own characteristics. Pending further study of the penetrating power on the deep dermis by UVA alone and the injury mechanism of dermis is urgent.

关 键 词：紫外线 光老化 机制 

分 类 号：R758[医药卫生—皮肤病学与性病学]