有机泡沫浸渍法制备多孔生物玻璃支架的研究  

Study on Porous Bioglass Scaffold Prepared by Dipping with Polymer Foams

作　　者：谢林[1,2] 陈晓峰[1,2] 赵娜如[1,2] 郭常亮[1,2] 

机构地区：[1]华南理工大学材料学院生物材料研究所,广州510640 [2]华南理工大学特种功能材料教育部重点实验室,广州510640

出　　处：《无机材料学报》2009年第2期280-284,共5页Journal of Inorganic Materials

基　　金：国家自然科学基金(50732003;50672028;50702023);广东省教育部产学研结合项目(007B09400123)

摘　　要：选用58S生物活性玻璃粉体为原料,利用预先处理过的聚氨酯泡沫作为模板,制备了一种孔隙率高,贯通性好,孔径可控的生物玻璃多孔支架.并通过排水法、X射线衍射(XRD)、扫描电子显微镜(SEM)及傅里叶红外光谱(FTIR)等方法研究和表征了多孔支架的显气孔率、晶相组成、显微形貌和生物活性.结果表明,浸料一次所得支架的显气孔率为93%左右,浸料二次下降为80%左右;在SBF溶液中,随着时间的延长,材料表面最初形成的颗粒状钙磷化合物逐渐矿化生成叶片状碳酸羟基磷灰石(HCA)层,表明该材料恒温37℃时具有较好的生物矿化性能和生物活性.The porous bioglass scaffolds with high porosity and interconnectivity and controllable pore size were prepared by using the powder of sol-gel derived bioactive glass-58S as the material and the pre-pro- duced polymer foam as the template. The apparent porosity, crystalline phases, micro-morphologies and bio- activity were investigated by using Archimedes drainage method, X-ray Diffraction （XRD） , Scan emission Microscope （SEM） and Fourier Transform Infrared Spectroscope （FTIR） techniques. The results show that the apparent porosity of the porous scaffolds can reach about 93% when the materials are dipped once, while the apparent porosity decreases to 80% after dipped twice. The originally formed amorphous-phosphorus compounds on the surface of samples are mineralized to hydroxyl-earbonate-apatite （HCA） with increasing dipping time in the SBF solution as the reaction progressed. So it can be concluded that this kind of material has good bio-mineralization property and bioactivity in SBF solution at the constant temperature of 37℃.

关 键 词：生物活性玻璃 有机泡沫浸渍法 多孔支架 碳酸羟基磷灰石 

分 类 号：R318[医药卫生—生物医学工程] TQ171[医药卫生—基础医学]