“类乒乓球”状壳聚糖微球对环丙沙星的控制释放性能的研究  

The control release ciprofloxacin of chitosan microsphere

作　　者：王珊[1] 郭金婵[1] 曹蕾[1] 古元梓[1] 杨光[1] 

机构地区：[1]咸阳师范学院化学系,陕西咸阳712000

出　　处：《应用化工》2009年第2期189-193,共5页Applied Chemical Industry

基　　金：陕西省教育厅专项科研计划资助项目(08JK482);咸阳师范学院专项基金(08XSYK109)

摘　　要：以甲醛作为交联剂,通过悬浮交联法得到单分散性的微米级微球。采用分光光度法研究了壳聚糖微球对环丙沙星的载药释药性能,考察了环丙沙星初始浓度、pH、微球粒径大小、载药时间及温度对饱和吸附量的影响。结果表明,在初始浓度为200 mg/L,pH为8.80和时间为65 min,温度为37℃的优化条件下,壳聚糖微球对环丙沙星的载药量最大,最大吸附量为325 mg/g。在pH为7.4,温度为37℃的模拟人体肠胃缓冲溶液(NaH2PO4/NaOH)中研究了初始浓度以及释放时间对释放结果的影响。实验表明,环丙沙星在担载时与环丙沙星的初始浓度有关,浓度越大,担载量越大,但是担载效率和浓度之间无确定的线性关系。在环丙沙星释放初期有明显的释放现象,但是随着时间的推移,药物释放逐渐稳定,释药效率可达97%左右。The chitosan microspheres were prepared by suspension crosslinking technique. Their properties were determined and analysed by SEM and IR spectrometer. The experiment results indicated the initial concentration of ciprofloxacin, pH, particle size, the drug time and temperature on adsorption saturation effects. The results showed that the initial concentration of 200 mg/g, pH of 8.80, time for the bleading of 65 min and temperature of 37℃, chitosan microspheres loaded eiprofloxacin largest, it is 325 mg/g. In conditions of pH 7.4 at 37 ℃ which simulate the human gastrointestinal solution （ NaH2PO4/NaOH）. The result showed that eiprofloxacin release in the early release of a suddenly phenomenon, but as time goes by drug release variable stability, sustained release efficiency up to 97%.

关 键 词：壳聚糖微球 环丙沙星 载药 释放 

分 类 号：O631[理学—高分子化学]