含胆酸酯侧基梳状均聚物和共聚物的制备和特性研究  

Synthesis and Characterization of Comb-Homopolymers and Copolymers Containing Cholate Side Group

作　　者：蒋树海[1,2] 胡祥正[2] 刘靖[2] 刘雁红[2] 

机构地区：[1]天津市科技创业服务中心,天津300192 [2]天津科技大学理学院,天津300457

出　　处：《高分子通报》2009年第3期36-41,共6页Polymer Bulletin

基　　金：天津市科技型中小企业创新基金资助项目(项目编号:08ZXCXSH05300)

摘　　要：以盐酸为催化剂合成了胆酸酯(2a～2d);用甲基丙烯酸酐(MAA)做酰化剂,4-二甲氨基吡啶(DMAP)做催化剂,三乙胺(Et3N)做缚酸剂,对2a～2d分子中伯羟基选择酰化,合成了分子中含有一个乙烯基的胆酸衍生物(3a～3d);应用溶液聚合方法制备了3a～3d均聚物及3a～3d与N-异丙基丙烯酰胺(NIPAA)的共聚物,并研究了聚合物的性能。结果显示:pH值为3～4时,反应得到2a～2d的产率最高;MAA做酰化剂,2a～2d分子中的伯羟基优先发生酰化反应;以胆酸为侧基的线性高分子化合物的性质随着二醇碳原子数增加而呈规律性变化。Polymers can be made from natural compounds like bile acids as an effort to be more biocompatible. Cholic acid, one of the common bile acids, has been coupled with diols containing 2, 4, 6 or 8 carbons through esterification. These cholates were further transformed into macromonomers by reacting with methacryloyl anhydride （MAA） as the acrylating agents. Multi-functional homopolymers and copolymers with thermosensitive Nisopropylacrylamide have been prepared and characterized. The results shew that the length of the aliphatic chains of the diols had a significant effect on the properties of resulted polymers.

关 键 词：胆酸衍生物 甲基丙烯酸酯 合成 温度敏感高分子化合物 

分 类 号：O631[理学—高分子化学]