邻氯苯乙烯合成工艺优化  

Optimization of Synthesis Technology of o-Chlorostyrene

作　　者：陈言德[1] 

机构地区：[1]扬子江药业集团有限公司江苏(泰州)新药研究院,江苏泰州225321

出　　处：《精细化工中间体》2009年第1期59-61,共3页Fine Chemical Intermediates

摘　　要：邻氯苯乙烯由邻氯苯乙酮经相转移催化还原、脱水、精馏等工艺制备。工艺总收率74%,纯度大于99%。在还原反应中以苄基三乙基氯化铵为相转移催化剂(催化剂用量为邻氯苯乙酮质量的2%),并且在精馏过程中使用2,4,6-三硝基苯酚作为阻聚剂(阻聚剂用量为邻氯苯乙醇质量的2.5%),避免了过程中邻氯苯乙烯的分子间聚合。o-Chlorostyrene was synthesized from o-chloroacetophenone 74% yield and 99% purity in three steps, including phase-transfer catalytic reduction, dehydration and distillation. The optimum conditions were obtained： the mass ratio of the catalyst BTEAC to o-chloroacetophenone 2%, of the inhibitor 2,4,6-trinitrophenol to o- chloroacetophenone 2.5%.

关 键 词：邻氯苯乙烯 相转移催化 苄基三乙基氯化铵 2 4 6-三硝基苯酚 还原 脱水 

分 类 号：TQ242.1[化学工程—有机化工]