不同类型钙通道阻滞剂对小鼠变应性接触性皮炎及表皮郎格罕细胞的影响  

The Effects of Different Categories of Calcium Channel Blockers on Murine Allergic Contact Dermatitis and Langerhans Cells.

作　　者：宋智琦[1] 林熙然[1] 

机构地区：[1]大连医科大学附属第一医院皮肤科

出　　处：《中国皮肤性病学杂志》1998年第3期137-139,共3页The Chinese Journal of Dermatovenereology

摘　　要：为了探讨钙通道阻滞剂（ＣＣＢｓ）对迟发型超敏反应（ＤＨＲ）的作用及其机制，我们观察了三类８种ＣＣＢｓ对小鼠变应性接触性皮炎（ＡＣＤ）及表皮郎格罕细胞（ＬＣｓ）的影响。结果发现Ⅰ类ＣＣＢｓ异搏定、硫氮酮，Ⅱ类ＣＣＢｓ尼莫地平、尼群地平及Ⅲ类ＣＣＢｓ脑益嗪在抑制ＤＨＲ的同时，亦减少表皮ＬＣｓ数。提示上述药物可通过降低表皮ＬＣｓ数而抑制ＤＨＲ。另外３种Ⅱ类ＣＣＢｓ心痛定、尼卡地平及络活喜亦显著抑制小鼠ＡＣＤ，但并未显示同时减少表皮ＬＣｓ数，提示ＣＣＢｓ对ＡＣＤ抑制作用的机理可能因药而异。Objective To study the role of calcium channel blockers (CCBs) in delayed hypersensitivity reaction (DHR).Method The effects of eight CCBs belonging to 3 categories on murin allergic contacct dermatitis (ACD) and epidermal Langerhans cells (LCs) were observed.Results CCBs of category I,verapamil hydrochloride and diltiazem,CCBs of category Ⅱ,nimodipine and nitrendipine,and CCBs of category Ⅲ stugeron,could suppress DHR and simultaneously reduce the number of epidermal LCs,suggesting that these CCBs suppress DHR by reducing the number of epidermal LCs.Other 3 CCBs of category Ⅱ,nifedipine,perdipine,and amilodipine besylate,also siginificantly suppressed murine ACD,but did not reduce the number of epidermal LCs.Condusion Different kinds of CCBs may suppress ACD with different echanisms.

关 键 词：钙通道阻滞剂 变应性 接触性皮炎 郎格罕细胞 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]