人类血小板1～16基因多态性与脑梗死相关性研究  

Study on the assosiation between genetic polymorphism of human platelet antigens 1-16 systems and cerebral infarction

作　　者：乐嘉宜[1] 瞿益华[2] 吴建国[1] 刘建军[2] 赵伟康[1] 王向红[1] 王胜奎[1] 李志强[2] 

机构地区：[1]上海市黄浦区中西医结合医院,上海200010 [2]上海交通大学附属第六人民医院

出　　处：《临床血液学杂志》2009年第2期141-143,146,共4页Journal of Clinical Hematology

基　　金：上海市卫生局科研课题计划项目(No:2006-109)

摘　　要：目的:研究上海地区人类血小板抗原基因(HPA-1～16)多态性与脑梗死相关性。方法:采用PCR-SSP方法对103例上海地区脑梗死患者进行HPA1-16系统基因分型。结果:脑梗死组患者HPA-2b等位基因频率与正常对照组相互比较有差异(χ2=4.7201,P<0.05),脑梗死组患者的HPA-2b等位基因相关ab/bb基因型为30例(占29.13%),与正常对照组29例(占17.58%)相互比较有明显差异(χ2=4.2780,P<0.05);脑梗死组患者HPA-15a等位基因频率与正常对照组相互比较差异有统计学意义(χ2=20.2370,P<0.01),脑梗死组患者的HPA-15a等位基因相关aa/ab基因型为94例(占91.26%)与正常对照组134例(占81.21%)相互比较差异有统计学意义(χ2=4.2838,P<0.05)。结论:HPA-2b与HPA-15a等位基因可作为上海地区脑梗死患者的遗传易感性标志。Objective：To investigate the association between genetic polymorphism of human platelet antigens 1 -16 （HPA-1-16） systems and cerebral infarction. Method： HPA 1-16 systems genotypes were applied to 103 Shanghai patients with cerebral infarction via sequence-specific （PCR- SSP）. Result：There were difference （X^2=4. 7201, P〈0.05） between the frequency of HPA-2b allele of cerebral infraction group and the control group;and there were significant difference （X^2=4. 2780,P〈0.05） between the allele of HPA-2b of cerebral infraction with aa/bb genotypes （30 samples,29.13%） and the control group （29 samples, 17.58%）. There were difference （x^2 = 20. 2370, P〈0.05） between the frequency of HPA-15a allele of cerebral infraction group and the control group. There were significant differences （X^2= 4. 2838, P〈0.05） between the allele of HPA-15a of cerebral infraction group which had 94 samples of aa/bb genotype （91.26%） and the control group which had 134 samples （81.21%）. Conclusion：The allele of H PA-2b and H PA-15a may be used as the standards of genetic susceptibility among the patients with cerebral infarction in Shanghai.

关 键 词：血小板 抗原 基因 脑梗死 

分 类 号：R558[医药卫生—血液循环系统疾病]