复方胃利散抗大鼠消化性溃疡的作用  

Effect of compound Weili powder on experimental peptic ulcer in rats

作　　者：关冬梅[1] 周晓棉[1] 李靖菲[1] 孟静娟[2] 徐永鹏[1] 曹颖林[1] 

机构地区：[1]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016 [2]中国医科大学附属第四医院,辽宁沈阳110032

出　　处：《沈阳药科大学学报》2009年第3期225-229,共5页Journal of Shenyang Pharmaceutical University

摘　　要：目的考察复方胃利散(compound Weili powder,FFWLP)对动物实验性溃疡模型的影响。方法建立乙醇致大鼠胃溃疡模型,幽门结扎型大鼠胃溃疡模型,盐酸半胱氨酸致大鼠十二指肠溃疡模型及乙酸致大鼠十二指肠溃疡模型。结果复方胃利散对乙醇致大鼠胃溃疡有保护作用;对幽门结扎致大鼠胃溃疡有保护作用;对乙酸、盐酸半胱氨酸致大鼠十二指肠溃疡有明显的治疗作用,并能降低胃液酸性,显著升高十二指肠溃疡模型大鼠的肠黏膜PGE2含量。结论复方胃利散有很好的抗消化性溃疡的作用。Objective To observe the effect of compound Weili powder（WLP, traditional Chinese medicine） on peptic ulcer in rats. Methods The four models of ethanol-induced and pyloric ligated gastric ulcer in rats, cysteamine-induced and acetic acid-induced duodenal ulcer in rats were established. Results Compound Wei- li powder（WLP） significantly protected stomach from gastric ulcer damage induced by ethan61,pyloric ligation. Meanwhile, compound Weili powder （WLP）showed an obvious curative effect on duodenal ulcer caused by cysteamine, acetic acid; furthermore, it significantly reduced acidity of the gastric juice and increased the content of PGE2 in mucous membrane. Conclusions Compound Weili powder can inhibit the experimental peptic ulcer in rats.

关 键 词：复方胃利散 消化性溃疡 乙醇 幽门结扎 盐酸半胱氨酸 

分 类 号：R96[医药卫生—药理学]