Nd:YAG温热疗法与Ar^+激光光动力学疗法联合对小鼠S_(180)肉瘤作用的剂量选择研究  

DOSE SELECT OF HYPERTHERMIA INDUCED BY Nd:YAG LASER AND PHOTODYNAMIC THERAPY BY Ar+ LASER RADIATION IN COMBINATIONON THE TRANSPLANTED TUMOR IN CM MICE

作　　者：李晓原[1] 谭润初[1] 史宏敏[1] 

机构地区：[1]中山医科大学激光医学研究室

出　　处：《中国医学物理学杂志》1998年第2期77-79,共3页Chinese Journal of Medical Physics

摘　　要：本文以小鼠Ｓ１８０肉瘤为对象，研究了Ｎｄ：ＹＡＧ激光温热疗法与Ａｒ＋激光光动力学疗法联合对小鼠Ｓ１８０肉瘤的作用剂量选择及作用效果。实验分为激光温热疗法组、Ａｒ＋激光光动力学组、联合作用组及对照组等四组。激光温热疗法用Ｎｄ：ＹＡＧ激光照射肿瘤，功率密度由实验确定约为４２４ｍＷ／ｃｍ２，控制肿瘤边缘温度为４３℃照射３０ｍｉｎ；Ａｒ＋光动力学疗法为激光照射前２４小时小鼠腹腔注射ＨｐＤ（１０ｍｇ／ｋｇ），以实验确定的１５０ｍＷ／ｃｍ２Ａｒ＋激光照射１５ｍｉｎ。结果表明，在所选定的剂量下，联合作用组肿瘤抑制率最高。说明联合作用方法值得进一步深入研究。The present paper reports the dose select and the effect of hyperthermia (HT) induced by Nd:YAG laser and photodynamic therapy (PDT) by Ar+ laser radiation in combination on the transplanted sarcoma 180 in CM mice.Tumorbearing mice were divided into four groups: A) control group,B)HT group,C) PDT group and D) PDT followed by HT group.HT was induced by Nd:YAG laser radiation and the temperature in tumor edge was control at 43℃ (about 424mW/cm2) for 30 minutes.Tumorbearing mice of group C and D were given an i.p. injection of HpD (10mg/kg )24 hours prior to Ar+ laser radiation (150mW/cm2 for 15 min). The experiments show significant increases in inhibition rates against the S180 in CM mice by the HT and PDT combination at the selected dose,compared to those by either HT or PDT alone.With that of Group D being the highest.The results suggest the combination of HT induced by Nd:YAG and PDT by Ar+ laser radiation may become a new method of tumor treatment.It is recommended that the combination method by studied further based on the experimental results.

关 键 词：激光温热疗法 光动力学疗法 ND:YAG激光 

分 类 号：R454.2[医药卫生—治疗学]