变异链球菌密度感应系统调控变链素的研究进展  

Research progress of mutacins regulated by quorum sensing in Streptococcus mutans

作　　者：王蔚璐[1] 凌均棨[1] 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院牙体牙髓病科,广东广州510055

出　　处：《国际口腔医学杂志》2009年第2期165-167,共3页International Journal of Stomatology

基　　金：广东省自然科学基金资助项目(06021623)

摘　　要：密度感应是指细菌根据菌群密度的变化分泌和感应信号分子-感受态调节肽(CSP),调控相关基因的表达。变链素是变异链球菌合成分泌的抗菌性多肽,在菌群中可调节相关细菌的生物学行为。变异链球菌密度感应系统可调控变链素的合成和分泌,参与菌群间的交流,调控牙菌斑生物膜的稳定性。下面就近年来受密度感应系统调控的变链素的研究进展作一综述。Quorum sensing is a process of cell-to-cell communication in Streptococcus mutans which secretes a special signal molecule-competence stimulating peptide （CSP）, then to induce and to activate the expression of related genes. Mutacin is antimicrobial substance produced by Streptococcus mutans, which coordinates biological behavior of related bacteria. However, quorum sensing can regulate mutacin to communicate with oral bacteria and regulate the stability of biofilm. This review summarized the reserch progress of mutacins regulated by quorum sensing in Streptococcus mutans in recent years.

关 键 词：变异链球菌 密度感应 变链素 

分 类 号：R378[医药卫生—病原生物学]