(-)表没食子儿茶素-3-O-没食子酸酯(EGCG)的抗流感病毒实验  

Study on the effect of anti-influenza virus of EGCG

作　　者：谭文界[1] 石丽桥[2] 祝汪洋 谭静玲 

机构地区：[1]湖北中医学院,湖北武汉430061 [2]武汉大学医学院病毒所,湖北武汉430000 [3]武汉双龙药业有限公司,湖北武汉430000 [4]湖北省药品检验所,湖北武汉430063

出　　处：《中国医院药学杂志》2009年第5期376-378,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究(-)表没食子儿茶素-3-O-没食子酸酯(EGCG,epigallocatechin-3-O-gallate)的抗流感病毒活性。方法:色谱分离单体,波谱鉴定,细胞培养测定抗病毒效价。结果:EGCG具有很强的体外抗流感病毒作用,TI>60,量效关系明显。结论:EGCG抗流感病毒效价高,毒性低,安全范围宽。OBJECTIVE To investigate the anti-influenza virus activity of compound EGCG. METHODS The compound was isolated and identified by chromatography,spectroanalysis. RESULTS The effect and potency of anti influenza virus were examined in vitro in cell culture; There was a close relationship between dose and efficacy of EGCG on the effect of anti influenza virus. CONCLUSION EGCG possesses potent inhibitory effect on influenza virus.

关 键 词：EGCG 抗流感病毒 

分 类 号：R943[医药卫生—药剂学]