复方甘草酸苷对抗结核药所致肝损害疗效观察  

Clinical evaluation of compound glycyrrhizin for treatment of antituberculous drug-induced liver disease

作　　者：周英[1] 关玉娟[2] 

机构地区：[1]广州市第八人民医院,广东广州510060 [2]广州市传染病医院,广东广州510060

出　　处：《中国医院药学杂志》2009年第5期394-396,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察复方甘草酸苷治疗抗结核药物所致药物性肝病临床效果和安全性。方法:42例患者随机分为治疗组21例,给予复方甘草酸苷治疗;对照组21例,给予能量合剂等基础治疗。治疗前后分别观察患者症状和体征、肝功能及B超检测肝脾大小。结果:复方甘草酸苷治疗后患者临床症状、肝功能均有显著改善。治疗组与对照组比较,显效率及总有效率的差异均有显著性(P<0.05)。结论:复方甘草酸苷治疗抗结核药所致的中毒性肝炎有显著疗效,安全。OBJECTIVE To observe the changes of clinical situation and liver function of the antituberculous drug-induced liver disease （DILD） treated by Compound Glycyrrhizin, and to discuss the curative efficacy and security of Compound Glycyrrhizin. METHODS 42 patients with antituberculous DILD were randomized into either therapy group （2l cases treated by Compound Glycyrrhizin） or control group （2l cases, basal treatment such as energy mixture）. The efficacy and safety were e valuated with clinical biochemical parameters and the size of liver and spleen. RESULTS After 30 days treatment, the clinical symptoms and biochemical parameters were improved in therapy group. The efficiency was significantly higher in therapy group than that in control group （P〈0. 05）. CONCLUSION Compound Glycyrrhizin, with a good tolerance and safety, has a sound efficacy in the improvement of clinical symptoms and hepatic functions of antituberculous DILD patients. It is a perfect drug to treat DILD at present.

关 键 词：药物性肝病 复方甘草酸苷 抗结核治疗 

分 类 号：R51[医药卫生—内科学] R452[医药卫生—临床医学]