桂枝汤有效部位A对体温双向调节作用及其机理研究*——对下丘脑NE、DA、5-HT含量的影响  

DualDirectional Thermoregulation and Its Mechanism of Active Fraction A of Guizhi decoction ——Effect on NE,DA and 5HT in Hypothalamus of Rats

作　　者：霍海如[1] 李晓芹[1] 谭余庆[1] 郭淑英[1] 周爱香 田甲丽[1] 孙玉茹[1] 贺玉琢[1] 姜廷良[1] 

机构地区：[1]中国中医研究院中药研究所

出　　处：《中国实验方剂学杂志》1998年第3期14-16,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金

摘　　要：在酵母诱导的发热大鼠中，桂枝汤有效部位Ａ（Ｆｒ．Ａ）能降低下丘脑５－ＨＴ、ＮＥ、ＤＡ含量；在安痛定诱导的低体温大鼠中，能升高５－ＨＴ含量。结果提示，Ｆｒ．Ａ为桂枝汤体温双向调节作用的一种物质基础，影响中枢神经递质５－ＨＴ的水平是其机理之一；Active fraction A (Fr.A),isolated from Guizhi decoction, could lower body temperature along with a decrease of 5hydroxy tryptamine (5HT)content in hypothalamus in febrile rats induced by zymosa. On the other hand,it made fallen temperature rise and increased the 5HT level in hypothalamus in hypothemic rats induced by aminopyrine. The results showed that Fr.A regulate temperature in a dualdirection pattern and the mechanism was partially related with its influence on content of 5HT in hypothalamus; and its antipyretic effect was associated with its reducing the contents of NE and DA in hypothalamus.

关 键 词：桂枝汤 有效部位A 体温双向调节 NE 多巴胺 5-HT 

分 类 号：R289.5[医药卫生—方剂学]