用吸入组织扩散性核素^(133)Xe研究+GZ负荷下犬全身血液动态转移  

Study of whole body blood shift in dog under +G Z stress using tissue diffusing nuclide 133 Xe

作　　者：李宪玉[1,2] 宣恒锐[1,2] 钟秋海 成奇明[1,2] 柴丽佳[1,2] 袁国英 李广道 颜桂定[1,2] 聂金玺 耿喜臣[1,2] 

机构地区：[1]空军航空医学研究所 [2]北京理工大学

出　　处：《中华航空航天医学杂志》1998年第1期9-1,共1页Chinese Journal of Aerospace Medicine

基　　金：国防科工委预研基金

摘　　要：目的为了探讨能否用吸入辐射损伤小（辐射损伤仅为Ｘ线检查的１／２０～１／３０）的氙（１３３Ｘｅ），取代注射锝（９９ｍＴｃ）研究＋ＧＺ负荷下全身血液动态转移的客观规律。以便使该法能推广应用于人体。方法用吸入对于人体相当安全的组织扩散性核素１３３Ｘｅ标记犬血液，测得Ｇ负荷下由头至臀８个部位的１３３Ｘｅ的饱和及清除曲线。用去本底法进行处理，从１３３Ｘｅ的饱和及清除曲线中分离出Ｇ负荷致血容动态变化活性曲线，进行校正后与用注射非组织扩散性核素９９ｍＴｃ法测得的结果进行比较研究。结果用吸入１３３Ｘｅ示踪剂法得到的Ｇ负荷去本底清除曲线，经校正后，与用注射９９ｍＴｃ法测得的Ｇ负荷血容曲线很相似。结论可以用吸入１３３Ｘｅ法取代注射９９ｍＴｃ法。Objective To explore the feasibility of using 133 Xe inhalation instead of 99m Tc injection for measurement of dynamic curves of whole body blood shift under +G Z stress in order to minimize radiation damage. Methods Tissue diffusing radioactive nuclide 133 Xe, fairly safe for human body, was used to label blood of the experimental dog. The saturation and clearance curves of 8 parts of the body (from head to buttocks) during +G Z exposures were obtained using radiation detectors. Treating with background elimination method the dynamic blood volume change curves during +G Z stress were separated from saturation and clearance curves. The blood volume curves during +G Z stress using nontissue diffusing nuclide 99m Tc were also measured for comparison. Results The rectified de background clearance curves obtained using 133 Xe as radioactive tracer were similar to those obtained using 99m Tc as tracer. Conclusion It is promising to use 133 Xe inhalation instead of 99m Tc injection for investigation of whole body blood shift under +G Z stress.

关 键 词：加速度 同位素示踪 血容量 

分 类 号：R852.21[医药卫生—航空、航天与航海医学]